RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain - Wikidata - awgldk - TriplyDB

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

http://www.wikidata.org/entity/Q27680635

about

Chemical genetics approaches for selective intervention in epigenetics Bromodomain Inhibitor Review: Bromodomain and Extra-terminal Family Protein Inhibitors as a Potential New Therapy in Central Nervous System Tumors The bromodomain: from epigenome reader to druggable target Dual kinase-bromodomain inhibitors for rationally designed polypharmacology Selective Chemical Modulation of Gene Transcription Favors Oligodendrocyte Lineage Progression Novel concepts in HDL pharmacology.Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells Cholesterol, inflammation and innate immunity RSK3: A regulator of pathological cardiac remodeling Targeting bromodomains: epigenetic readers of lysine acetylation The mechanisms behind the therapeutic activity of BET bromodomain inhibition Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery Targeting BET bromodomains for cancer treatment A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4 Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD.BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.Drug Discovery Targeting Bromodomain-Containing Protein 4.Selective BET bromodomain inhibition as an antifungal therapeutic strategy Privileged diazepine compounds and their emergence as bromodomain inhibitors.BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma HDL and cognition in neurodegenerative disorders.BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo.Brd4 is essential for IL-1β-induced inflammation in human airway epithelial cells Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.Alternative modulation of protein-protein interactions by small molecules Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery Molecular docking and dynamics simulation study of flavonoids as BET bromodomain inhibitors.Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.Design and characterization of bivalent BET inhibitors.Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET.Accurate calculation of the absolute free energy of binding for drug molecules.Selective and reversible suppression of intestinal stem cell differentiation by pharmacological inhibition of BET bromodomains The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease Modeling cis-regulation with a compendium of genome-wide histone H3K27ac profiles.Bromodomain and extra-terminal protein mimic JQ1 decreases inflammation in human vascular endothelial cells: Implications for pulmonary arterial hypertension.Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration.Epigenetic drug discovery for Alzheimer's disease.

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RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

http://www.wikidata.org/entity/Q27680635

description

2013 nî lūn-bûn

@nan

2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

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2013年論文

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2013年论文

@wuu

name

RVX-208, an inhibitor of BET t ...... ity for the second bromodomain

@ast

RVX-208, an inhibitor of BET t ...... ity for the second bromodomain

@en

RVX-208, an inhibitor of BET t ...... ity for the second bromodomain

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type

label

RVX-208, an inhibitor of BET t ...... ity for the second bromodomain

@ast

RVX-208, an inhibitor of BET t ...... ity for the second bromodomain

@en

RVX-208, an inhibitor of BET t ...... ity for the second bromodomain

@nl

prefLabel

RVX-208, an inhibitor of BET t ...... ity for the second bromodomain

@ast

RVX-208, an inhibitor of BET t ...... ity for the second bromodomain

@en

RVX-208, an inhibitor of BET t ...... ity for the second bromodomain

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PNAS.1310658110

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

RVX-208, an inhibitor of BET t ...... ity for the second bromodomain

@en

P2093

Beatriz Diez-Dacal

http://www.w3.org/2001/XMLSchema#string

Chas Bountra

http://www.w3.org/2001/XMLSchema#string

Christopher Wells

http://www.w3.org/2001/XMLSchema#string

Deborah Brotherton

http://www.w3.org/2001/XMLSchema#string

Hannah Lingard

http://www.w3.org/2001/XMLSchema#string

Ildiko Felletar

http://www.w3.org/2001/XMLSchema#string

Martin Philpott

http://www.w3.org/2001/XMLSchema#string

Sarah Martin

http://www.w3.org/2001/XMLSchema#string

P2860

Bioconductor: open software development for computational biology and bioinformatics

Structure and ligand of a histone acetyltransferase bromodomain

Selective inhibition of BET bromodomains

Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells

Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting

Histone recognition and large-scale structural analysis of the human bromodomain family

A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p

Small-molecule inhibition of BRDT for male contraception.

c-Myc regulates transcriptional pause release

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19754-9

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scholarly article

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1185938

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10.1073/PNAS.1310658110

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P433

49

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110

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Panagis Filippakopoulos

Susanne Müller

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2013-12-03T00:00:00Z

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24248379

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3856850

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