Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket
about
Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertensionGenome-wide network-based pathway analysis of CSF t-tau/Aβ1-42 ratio in the ADNI cohort.Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonanceInactivation of multiple bacterial histidine kinases by targeting the ATP-binding domain.Molecular docking studies of (4Z, 12Z)-cyclopentadeca-4, 12-dienone from Grewia hirsuta with some targets related to type 2 diabetesDiffering roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.Pyruvate dehydrogenase kinase regulates hepatitis C virus replication.The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents.Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy.Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.High-precision, automated integration of multiple isothermal titration calorimetric thermograms: new features of NITPICInhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.Resorcinol-Based Grp94-Selective Inhibitors.Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.Structural ensemble-based docking simulation and biophysical studies discovered new inhibitors of Hsp90 N-terminal domain.Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex.Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice.A Novel Inhibitor of Pyruvate Dehydrogenase Kinase Stimulates Myocardial Carbohydrate Oxidation in Diet-Induced Obesity.Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
P2860
Q26774957-3E99410F-0843-4BD9-BC91-D58C05AF8CC5Q28083183-02972D0C-15D8-46CC-BBBC-62C334EE41C4Q33743209-745855DF-2619-47A7-9FF4-B524AB8DE431Q34972253-A198E910-B44C-4A7F-817A-218D9E05C12FQ34992446-C9FB5F22-6D08-4AAE-A539-81ED7D24E0D4Q35606228-BF16A34D-53E7-4EE1-80C0-BAFB6E670361Q35878096-D50953E0-65F7-487C-81BF-03380B6F00E3Q37137222-371112D5-037D-4B57-83AD-1BEBF27C703EQ38418672-4850D215-8A6F-4ED0-8C92-BF5D65E6CE8EQ38652550-D671E3D0-082D-4ADB-B9D1-446B45A35034Q41358539-A82346FF-731B-489A-91F3-FAAADF7EE139Q41669619-D9F0D847-C884-463E-95FD-7D5EEFB13AEEQ47410087-FA1EF596-4B9B-4A6C-863E-6BCA6B14908AQ47615969-BA278769-6C37-453D-8350-0F352144A7E6Q47619180-DD3D7E7A-BC91-40B9-A205-51F4DF3DF916Q48353659-2D433694-9F14-4690-95F2-D3727162AEE1Q48542611-3CC09931-1D59-4A9E-A3BF-E763BA3AA361Q51730967-00718156-54DF-4538-A432-2DC2421F6389Q52321260-0FCD48FE-8967-47C1-AC57-04CF03416212Q54111494-AE922480-A6E0-44A0-B461-54347021DCB9Q58730034-E57FC6CC-859A-43D1-97A2-16B5879B3857
P2860
Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket
description
2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Structure-guided Development o ...... rgeting the ATP-binding Pocket
@ast
Structure-guided Development o ...... rgeting the ATP-binding Pocket
@en
Structure-guided Development o ...... rgeting the ATP-binding Pocket
@nl
type
label
Structure-guided Development o ...... rgeting the ATP-binding Pocket
@ast
Structure-guided Development o ...... rgeting the ATP-binding Pocket
@en
Structure-guided Development o ...... rgeting the ATP-binding Pocket
@nl
prefLabel
Structure-guided Development o ...... rgeting the ATP-binding Pocket
@ast
Structure-guided Development o ...... rgeting the ATP-binding Pocket
@en
Structure-guided Development o ...... rgeting the ATP-binding Pocket
@nl
P2093
P2860
P50
P3181
P356
P1476
Structure-guided development o ...... rgeting the ATP-binding pocket
@en
P2093
David T Chuang
Jacinta L Chuang
Lorraine K Morlock
Noelle S Williams
Philipp E Scherer
Shih-Chia Tso
Uttam K Tambar
Wen-Jun Gui
P2860
P304
P3181
P356
10.1074/JBC.M113.533885
P407
P577
2013-12-19T00:00:00Z