Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1 - Wikidata - awgldk - TriplyDB

Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

http://www.wikidata.org/entity/Q27681060

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Fuzzy complexes: Specific binding without complete folding p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation p62/SQSTM1 functions as a signaling hub and an autophagy adaptor Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.Mechanisms and functions of Nrf2 signaling in Drosophila.Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway Cadmium and Secondary Structure-dependent Function of a Degron in the Pca1p Cadmium Exporter.Monitoring Keap1-Nrf2 interactions in single live cells.Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-Δ12, 14 -PGJ2.Structural basis of Keap1 interactions with Nrf2.Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters.Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants.An overview of the mechanisms and novel roles of Nrf2 in cardiovascular diseases.The KEAP1-NRF2 System in Cancer.A systematic molecular dynamics approach to the study of peptide Keap1-Nrf2 protein-protein interaction inhibitors and its application to p62 peptides.A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface.Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation.Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy.Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1.Nrf2, the Master Regulator of Anti-Oxidative Responses.Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma.KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane.NRF2 Addiction in Cancer Cells.The binding mechanism of a novel nicotinamide isostere inhibiting with TNKSs: a molecular dynamic simulation and binding free energy calculation.The mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding A catalogue of somatic NRF2 gain-of-function mutations in cancer

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Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

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2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Kinetic, Thermodynamic, and St ...... en Nrf2-DLGex Degron and Keap1

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Kinetic, Thermodynamic, and St ...... en Nrf2-DLGex Degron and Keap1

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Kinetic, Thermodynamic, and St ...... en Nrf2-DLGex Degron and Keap1

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Kinetic, Thermodynamic, and St ...... en Nrf2-DLGex Degron and Keap1

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Kinetic, Thermodynamic, and St ...... en Nrf2-DLGex Degron and Keap1

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Kinetic, Thermodynamic, and St ...... en Nrf2-DLGex Degron and Keap1

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Kinetic, Thermodynamic, and St ...... en Nrf2-DLGex Degron and Keap1

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Kinetic, Thermodynamic, and St ...... en Nrf2-DLGex Degron and Keap1

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Kinetic, Thermodynamic, and St ...... en Nrf2-DLGex Degron and Keap1

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Molecular and Cellular Biology

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Kinetic, thermodynamic, and st ...... en Nrf2-DLGex degron and Keap1

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Kenji Takagi

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Masayuki Yamamoto

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Noriaki Ohuchi

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Toshiaki Fukutomi

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P2860

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

PHENIX: a comprehensive Python-based system for macromolecular structure solution

The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy

Coot: model-building tools for molecular graphics

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832-846

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scholarly article

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1217492

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10.1128/MCB.01191-13

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5

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34

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Tsunehiro Mizushima

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2013-12-23T00:00:00Z

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24366543

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Nuclear factor, erythroid derived 2, like 2

Kelch-like ECH-associated protein 1

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4023822

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