From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters
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Replacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT)Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibitionMolecular recognition in chemical and biological systems.Nexus between protein-ligand affinity rank-ordering, biophysical approaches, and drug discovery.Flooding enzymes: quantifying the contributions of interstitial water and cavity shape to ligand binding using extended linear response free energy calculations.An Immucillin-Based Transition-State-Analogous Inhibitor of tRNA-Guanine Transglycosylase (TGT).
P2860
From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters
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2012 nî lūn-bûn
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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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name
From lin-benzoguanines to lin- ...... ng by importing water clusters
@ast
From lin-benzoguanines to lin- ...... ng by importing water clusters
@en
From lin-benzoguanines to lin- ...... ng by importing water clusters
@nl
type
label
From lin-benzoguanines to lin- ...... ng by importing water clusters
@ast
From lin-benzoguanines to lin- ...... ng by importing water clusters
@en
From lin-benzoguanines to lin- ...... ng by importing water clusters
@nl
prefLabel
From lin-benzoguanines to lin- ...... ng by importing water clusters
@ast
From lin-benzoguanines to lin- ...... ng by importing water clusters
@en
From lin-benzoguanines to lin- ...... ng by importing water clusters
@nl
P2093
P2860
P50
P356
P1476
From lin-benzoguanines to lin- ...... ng by importing water clusters
@en
P2093
Andreas Heine
Björn Wagner
Florian Immekus
Luzi Jakob Barandun
Manfred Kansy
Sandro Tonazzi
Severin Wendelspiess
Tina Ritschel
P2860
P304
P356
10.1002/CHEM.201200809
P407
P577
2012-07-23T00:00:00Z