Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site
about
HIV-1 gp120 as a therapeutic target: navigating a moving labyrinthBinding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study.Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120.Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity.Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment.Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.Driving HIV-1 into a Vulnerable Corner by Taking Advantage of Viral Adaptation and Evolution.Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity.A broad spectrum anti-HIV inhibitor significantly disturbs V1/V2 domain rearrangements of HIV-1 gp120 and inhibits virus entry.Small-molecule HIV-1 entry inhibitors targeting gp120 and gp41: a patent review (2010-2015).Identification of Novel Potential gp120 of HIV-1 Antagonist Using Per-Residue Energy Contribution-Based Pharmacophore modelling.Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement.Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement.Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.A Small-Molecule CD4-mimetic Compound Protects BLT Humanized Mice from Human Immunodeficiency Virus Infection.A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge.
P2860
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P2860
Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site
description
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2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Crystal Structures of HIV-1 gp ...... at Target the CD4-Binding Site
@ast
Crystal Structures of HIV-1 gp ...... at Target the CD4-Binding Site
@en
Crystal Structures of HIV-1 gp ...... at Target the CD4-Binding Site
@nl
type
label
Crystal Structures of HIV-1 gp ...... at Target the CD4-Binding Site
@ast
Crystal Structures of HIV-1 gp ...... at Target the CD4-Binding Site
@en
Crystal Structures of HIV-1 gp ...... at Target the CD4-Binding Site
@nl
prefLabel
Crystal Structures of HIV-1 gp ...... at Target the CD4-Binding Site
@ast
Crystal Structures of HIV-1 gp ...... at Target the CD4-Binding Site
@en
Crystal Structures of HIV-1 gp ...... at Target the CD4-Binding Site
@nl
P2093
P2860
P1433
P1476
Crystal structures of HIV-1 gp ...... at target the CD4-binding site
@en
P2093
Amos B Smith
Asim K Debnath
David M Jones
Joel R Courter
Judith M LaLonde
Mark A Elban
Peter D Kwong
Yongping Yang
Young Do Kwon
P2860
P304
P356
10.1371/JOURNAL.PONE.0085940
P407
P577
2014-01-28T00:00:00Z