(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis

(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis

Item
http://www.wikidata.org/entity/Q27681634
(+)-Vitisin A inhibits osteoclast differentiation by preventing TRAF6 ubiquitination and TRAF6-TAK1 formation to suppress NFATc1 activationMolecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain InhibitorsAnti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitorsInsights from molecular modeling into the selective inhibition of cathepsin S by its inhibitor.A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin KStructural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor.Highly selective aza-nitrile inhibitors for cathepsin K, structural optimization and molecular modeling.Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.Advances in the discovery of cathepsin K inhibitors on bone resorption.
P2860

(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis

Item
http://www.wikidata.org/entity/Q27681634
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
(1R,2R)-N-(1-cyanocyclopropyl) ...... he treatment of osteoarthritis
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(1R,2R)-N-(1-cyanocyclopropyl) ...... he treatment of osteoarthritis
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(1R,2R)-N-(1-cyanocyclopropyl) ...... he treatment of osteoarthritis
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type
label
(1R,2R)-N-(1-cyanocyclopropyl) ...... he treatment of osteoarthritis
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(1R,2R)-N-(1-cyanocyclopropyl) ...... he treatment of osteoarthritis
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(1R,2R)-N-(1-cyanocyclopropyl) ...... he treatment of osteoarthritis
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prefLabel
(1R,2R)-N-(1-cyanocyclopropyl) ...... he treatment of osteoarthritis
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(1R,2R)-N-(1-cyanocyclopropyl) ...... he treatment of osteoarthritis
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(1R,2R)-N-(1-cyanocyclopropyl) ...... he treatment of osteoarthritis
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P1433
P1476
(1R,2R)-N-(1-cyanocyclopropyl) ...... he treatment of osteoarthritis
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P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921