Evolutionary history and metabolic insights of ancient mammalian uricases - Wikidata - awgldk - TriplyDB

Evolutionary history and metabolic insights of ancient mammalian uricases

Evolutionary history and metabolic insights of ancient mammalian uricases

http://www.wikidata.org/entity/Q27681817

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Uric acid in metabolic syndrome: From an innocent bystander to a central player An experimental phylogeny to benchmark ancestral sequence reconstruction PhyloBot: A Web Portal for Automated Phylogenetics, Ancestral Sequence Reconstruction, and Exploration of Mutational Trajectories Catalysis and Structure of Zebrafish Urate Oxidase Provide Insights into the Origin of Hyperuricemia in Hominoids Rapid bursts and slow declines: on the possible evolutionary trajectories of enzymes Site-specific albumination of a therapeutic protein with multi-subunit to prolong activity in vivo Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids Mutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history.New insights on the risk for cardiovascular disease in African Americans: the role of added sugars.The peroxisomal protein import machinery displays a preference for monomeric substrates.Functional Divergence of the Nuclear Receptor NR2C1 as a Modulator of Pluripotentiality During Hominid Evolution.Metabolic and Kidney Diseases in the Setting of Climate Change, Water Shortage, and Survival Factors Resurrecting ancestral structural dynamics of an antiviral immune receptor: adaptive binding pocket reorganization repeatedly shifts RNA preference.Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy.A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes.Development of Therapeutic Chimeric Uricase by Exon Replacement/Restoration and Site-Directed Mutagenesis Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling.Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview.Retrocyclins neutralize bacterial toxins by potentiating their unfolding.Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction Ancient insights into uric acid metabolism in primates.Pacific Populations, Metabolic Disease and 'Just-So Stories': A Critique of the 'Thrifty Genotype' Hypothesis in Oceania.Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.Soluble Uric Acid Activates the NLRP3 Inflammasome.C-peptide antioxidant adaptive pathways in β cells and diabetes.Physiological functions and pathogenic potential of uric acid: A review.A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice.The identification of an integral membrane, cytochrome c urate oxidase completes the catalytic repertoire of a therapeutic enzyme [Hyperuricemia and gout : New aspects of an old disease].Uric acid in plants and microorganisms: Biological applications and genetics - A review.Mechanism of high affinity inhibition of the human urate transporter URAT1 Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout.Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats.Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout.Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway.The sedentary (r)evolution: Have we lost our metabolic flexibility?Designing a mutant Candida uricase with improved polymerization state and enzymatic activity.Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins.

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Evolutionary history and metabolic insights of ancient mammalian uricases

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Evolutionary history and metabolic insights of ancient mammalian uricases

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Evolutionary history and metabolic insights of ancient mammalian uricases

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Evolutionary history and metabolic insights of ancient mammalian uricases

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Evolutionary history and metabolic insights of ancient mammalian uricases

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Evolutionary history and metabolic insights of ancient mammalian uricases

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Evolutionary history and metabolic insights of ancient mammalian uricases

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Proceedings of the National Academy of Sciences of the United States of America

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Evolutionary history and metabolic insights of ancient mammalian uricases

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P2860

When less is more: gene loss as an engine of evolutionary change

Urate oxidase: primary structure and evolutionary implications

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

Hyperstability and substrate promiscuity in laboratory resurrections of Precambrian β-lactamases

Coot: model-building tools for molecular graphics

Protein structure prediction on the Web: a case study using the Phyre server

PAML 4: phylogenetic analysis by maximum likelihood

Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes

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