Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)

Item
http://www.wikidata.org/entity/Q27682810
Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progressionExamination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10).A putative N-terminal nuclear export sequence is sufficient for Mps1 nuclear exclusion during interphaseDynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachmentGenetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.Modular elements of the TPR domain in the Mps1 N terminus differentially target Mps1 to the centrosome and kinetochore.Regulation of mitotic progression by the spindle assembly checkpointRemoval of a consensus proline is not sufficient to allow tetratricopeptide repeat oligomerization.Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint.
P2860

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)

Item
http://www.wikidata.org/entity/Q27682810
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structural and functional insi ...... (spindle assembly checkpoint)
@ast
Structural and functional insi ...... (spindle assembly checkpoint)
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Structural and functional insi ...... (spindle assembly checkpoint)
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type
label
Structural and functional insi ...... (spindle assembly checkpoint)
@ast
Structural and functional insi ...... (spindle assembly checkpoint)
@en
Structural and functional insi ...... (spindle assembly checkpoint)
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prefLabel
Structural and functional insi ...... (spindle assembly checkpoint)
@ast
Structural and functional insi ...... (spindle assembly checkpoint)
@en
Structural and functional insi ...... (spindle assembly checkpoint)
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P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Structural and functional insi ...... (spindle assembly checkpoint)
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698