Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329)
about
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)Continuous inhibition of 11β-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice.Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune.Design and synthesis of (R)-1-arylsulfonylpiperidine-2-carboxamides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
P2860
Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329)
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Novel acidic 11β-hydroxysteroi ...... ol-1-yl]benzoic acid (AZD8329)
@ast
Novel acidic 11β-hydroxysteroi ...... ol-1-yl]benzoic acid (AZD8329)
@en
Novel acidic 11β-hydroxysteroi ...... ol-1-yl]benzoic acid (AZD8329)
@nl
type
label
Novel acidic 11β-hydroxysteroi ...... ol-1-yl]benzoic acid (AZD8329)
@ast
Novel acidic 11β-hydroxysteroi ...... ol-1-yl]benzoic acid (AZD8329)
@en
Novel acidic 11β-hydroxysteroi ...... ol-1-yl]benzoic acid (AZD8329)
@nl
prefLabel
Novel acidic 11β-hydroxysteroi ...... ol-1-yl]benzoic acid (AZD8329)
@ast
Novel acidic 11β-hydroxysteroi ...... ol-1-yl]benzoic acid (AZD8329)
@en
Novel acidic 11β-hydroxysteroi ...... ol-1-yl]benzoic acid (AZD8329)
@nl
P2093
P3181
P356
P1476
Novel acidic 11β-hydroxysteroi ...... ol-1-yl]benzoic acid (AZD8329)
@en
P2093
Amanda Rees
Andrew Stocker
David Hargreaves
Derek J Ogg
Elaine Kilgour
James S Scott
Joanne deSchoolmeester
John G Swales
Martin J Packer
Nidhal Selmi
P304
P3181
P356
10.1021/JM301252N
P407
P577
2012-11-26T00:00:00Z