3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models

3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models

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http://www.wikidata.org/entity/Q27683554
In vivo administration of a JAK3 inhibitor during acute SIV infection leads to significant increases in viral load during chronic infectionAdvances in kinase inhibition: treating rheumatic diseases and beyond.In vivo administration of a JAK3 inhibitor to chronically siv infected rhesus macaques leads to NK cell depletion associated with transient modest increase in viral loads.Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.Pharmacophore and Virtual Screening of JAK3 inhibitors.Selective JAK inhibitors.Oxindole-based SYK and JAK3 dual inhibitors for rheumatoid arthritis: designing, synthesis and biological evaluation.Development of Selective Covalent Janus Kinase 3 Inhibitors.Highly selective Janus kinase 3 inhibitors based on a pyrrolo[2,3-d]pyrimidine scaffold: evaluation of WO2013085802.Molecular dynamics and integrated pharmacophore-based identification of dual [Formula: see text] inhibitors.Dual inhibitors of Janus kinase 2 and 3 (JAK2/3): designing by pharmacophore- and docking-based virtual screening approach.Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis.The role of ligand efficiency metrics in drug discovery.Ligand-based and e-pharmacophore modeling, 3D-QSAR and hierarchical virtual screening to identify dual inhibitors of spleen tyrosine kinase (Syk) and janus kinase 3 (JAK3).
P2860

3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models

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http://www.wikidata.org/entity/Q27683554
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
3-Amido pyrrolopyrazine JAK ki ...... in cellular and in vivo models
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3-Amido pyrrolopyrazine JAK ki ...... in cellular and in vivo models
@en
3-Amido pyrrolopyrazine JAK ki ...... in cellular and in vivo models
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type
label
3-Amido pyrrolopyrazine JAK ki ...... in cellular and in vivo models
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3-Amido pyrrolopyrazine JAK ki ...... in cellular and in vivo models
@en
3-Amido pyrrolopyrazine JAK ki ...... in cellular and in vivo models
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prefLabel
3-Amido pyrrolopyrazine JAK ki ...... in cellular and in vivo models
@ast
3-Amido pyrrolopyrazine JAK ki ...... in cellular and in vivo models
@en
3-Amido pyrrolopyrazine JAK ki ...... in cellular and in vivo models
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P1433
P1476
P2093
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P31
P356
P407
P433
P478
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P5875
P698
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P1433
P1476
3-Amido pyrrolopyrazine JAK ki ...... in cellular and in vivo models
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698