Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases
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CLASP2 Has Two Distinct TOG Domains That Contribute Differently to Microtubule DynamicsA second tubulin binding site on the kinesin-13 motor head domain is important during mitosisCytoplasmic dynein binding, run length, and velocity are guided by long-range electrostatic interactionsMultiscale method for modeling binding phenomena involving large objects: application to kinesin motor domains motion along microtubules.Kinesin-13 regulates the quantity and quality of tubulin inside cilia.Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular MachinesInsight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.Structural basis for the extended CAP-Gly domains of p150(glued) binding to microtubules and the implication for tubulin dynamics.A unique kinesin-8 surface loop provides specificity for chromosome alignmentThe contribution of αβ-tubulin curvature to microtubule dynamics.Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.Emergent Properties of the Metaphase Spindle.Structures of potent anticancer compounds bound to tubulinNew Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C.Distinct Interaction Modes of the Kinesin-13 Motor Domain with the Microtubule.Role and regulation of kinesin-8 motors through the cell cycleControl of microtubule organization and dynamics: two ends in the limelight.Non-equilibrium assembly of microtubules: from molecules to autonomous chemical robots.Molecular insight into the regulation and function of MCAK.HX-MS2 for high performance conformational analysis of complex protein states.The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch.Convolutional neural networks for automated annotation of cellular cryo-electron tomograms.The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition.Structural basis of human kinesin-8 function and inhibition.A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition.A molecular motor finds its track.Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s.Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.
P2860
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P2860
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases
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2013 թուականի Մարտին հրատարակուած գիտական յօդուած
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2013 թվականի մարտին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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name
Structural model for tubulin r ...... n-13 microtubule depolymerases
@ast
Structural model for tubulin r ...... n-13 microtubule depolymerases
@en
Structural model for tubulin r ...... n-13 microtubule depolymerases
@nl
type
label
Structural model for tubulin r ...... n-13 microtubule depolymerases
@ast
Structural model for tubulin r ...... n-13 microtubule depolymerases
@en
Structural model for tubulin r ...... n-13 microtubule depolymerases
@nl
prefLabel
Structural model for tubulin r ...... n-13 microtubule depolymerases
@ast
Structural model for tubulin r ...... n-13 microtubule depolymerases
@en
Structural model for tubulin r ...... n-13 microtubule depolymerases
@nl
P2093
P3181
P1433
P1476
Structural model for tubulin r ...... n-13 microtubule depolymerases
@en
P2093
Ana B Asenjo
Chandrima Chatterjee
Dongyan Tan
Hernando Sosa
Mariena Silvestry
Ruben Diaz-Avalos
Vania DePaoli
William J Rice
P304
P3181
P356
10.1016/J.CELREP.2013.01.030
P577
2013-03-28T00:00:00Z