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Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulationCrystal structure of a hypothetical protein, TTHA0829 from Thermus thermophilus HB8, composed of cystathionine-β-synthase (CBS) and aspartate-kinase chorismate-mutase tyrA (ACT) domainsTwo classes of bacterial IMPDHs according to their quaternary structures and catalytic propertiesMg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporterQuantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis.Cytoophidium assembly reflects upregulation of IMPDH activity.Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases.The cystathionine-β-synthase domains on the guanosine 5''-monophosphate reductase and inosine 5'-monophosphate dehydrogenase enzymes from Leishmania regulate enzymatic activity in response to guanylate and adenylate nucleotide levels.Metabolic regulation via enzyme filamentationInosine 5'-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives.The Bare Essentials of Antibiotic Target Validation.Benzoxazoles, phthalazinones, and arylurea-based compounds with IMPDH-independent antibacterial activity against Francisella tularensis.Cystathionine β-synthase (CBS) domains confer multiple forms of Mg2+-dependent cooperativity to family II pyrophosphatases.A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.Reconstituted IMPDH polymers accommodate both catalytically active and inactive conformations.Interaction of intramembrane metalloprotease SpoIVFB with substrate Pro-σK.Diadenosine tetraphosphate (Ap4A) - an E. coli alarmone or a damage metabolite?Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.IMP/GTP balance modulates cytoophidium assembly and IMPDH activity.Interfilament interaction between IMPDH and CTPS cytoophidia
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
MgATP regulates allostery and fiber formation in IMPDHs
@ast
MgATP regulates allostery and fiber formation in IMPDHs
@en
MgATP regulates allostery and fiber formation in IMPDHs
@nl
type
label
MgATP regulates allostery and fiber formation in IMPDHs
@ast
MgATP regulates allostery and fiber formation in IMPDHs
@en
MgATP regulates allostery and fiber formation in IMPDHs
@nl
prefLabel
MgATP regulates allostery and fiber formation in IMPDHs
@ast
MgATP regulates allostery and fiber formation in IMPDHs
@en
MgATP regulates allostery and fiber formation in IMPDHs
@nl
P2093
P50
P3181
P1433
P1476
MgATP regulates allostery and fiber formation in IMPDHs
@en
P2093
Bertrand Raynal
Isabelle Salard-Arnaud
Joséphine Lai Kee Him
Laurène Vaupré
Thomas Alexandre
P304
P3181
P356
10.1016/J.STR.2013.03.011
P577
2013-05-02T00:00:00Z