Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV-1 Protease

Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV-1 Protease

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http://www.wikidata.org/entity/Q27684933
Effects of Hinge Region Natural Polymorphisms on Human Immunodeficiency Virus-1 Protease Structure, Dynamics and Drug-Pressure EvolutionEffects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by Amprenavir and Darunavir.Highly resistant HIV-1 proteases and strategies for their inhibition.Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance.Interdependence of Inhibitor Recognition in HIV-1 Protease.Pulsed EPR characterization of HIV-1 protease conformational sampling and inhibitor-induced population shifts.Improving Viral Protease Inhibitors to Counter Drug Resistance.Decoding HIV resistance: from genotype to therapy.Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.Elucidating the Interdependence of Drug Resistance from Combinations of Mutations.De novo active sites for resurrected Precambrian enzymes.Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease.The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance.Role of Conformational Motions in Enzyme Function: Selected Methodologies and Case Studies.Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease
P2860

Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV-1 Protease

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http://www.wikidata.org/entity/Q27684933
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2014 nî lūn-bûn
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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2014 թվականի օգոստոսին հրատարակված գիտական հոդված
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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Drug Resistance Conferred by M ...... ral Ensemble of HIV-1 Protease
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Drug Resistance Conferred by M ...... ral Ensemble of HIV-1 Protease
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Drug Resistance Conferred by M ...... ral Ensemble of HIV-1 Protease
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Drug Resistance Conferred by M ...... ral Ensemble of HIV-1 Protease
@ast
Drug Resistance Conferred by M ...... ral Ensemble of HIV-1 Protease
@en
Drug Resistance Conferred by M ...... ral Ensemble of HIV-1 Protease
@nl
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Drug Resistance Conferred by M ...... ral Ensemble of HIV-1 Protease
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Drug Resistance Conferred by M ...... ral Ensemble of HIV-1 Protease
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Drug Resistance Conferred by M ...... ral Ensemble of HIV-1 Protease
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P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
Drug Resistance Conferred by M ...... ral Ensemble of HIV-1 Protease
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932