Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA
about
A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhAN-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular ActivityWhat is a "DNA-Compatible" Reaction?Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded LibraryBiological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosisA DNA-templated synthesis of encoded small molecules by DNA self-assembly.Direct inhibitors of InhA are active against Mycobacterium tuberculosis.Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library.Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins.Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library.The tuberculosis drug discovery and development pipeline and emerging drug targets.Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights.Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm InhibitorsDiscovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections.An Integrated Microfluidic Processor for DNA-Encoded Combinatorial Library Functional ScreeningAntitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.Tuberculosis drug discovery and emerging targets.Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target.New structural classes of antituberculosis agents.Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets.Identification of InhA inhibitors: A combination of virtual screening, molecular dynamics simulations and quantum chemical studies.A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition
P2860
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P2860
Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA
description
2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Encoded library technology as ...... ycobacterium tuberculosis InhA
@ast
Encoded library technology as ...... ycobacterium tuberculosis InhA
@en
Encoded library technology as ...... ycobacterium tuberculosis InhA
@nl
type
label
Encoded library technology as ...... ycobacterium tuberculosis InhA
@ast
Encoded library technology as ...... ycobacterium tuberculosis InhA
@en
Encoded library technology as ...... ycobacterium tuberculosis InhA
@nl
prefLabel
Encoded library technology as ...... ycobacterium tuberculosis InhA
@ast
Encoded library technology as ...... ycobacterium tuberculosis InhA
@en
Encoded library technology as ...... ycobacterium tuberculosis InhA
@nl
P2093
P50
P3181
P356
P1476
Encoded library technology as ...... ycobacterium tuberculosis InhA
@en
P2093
Alfonso Mendoza-Losana
Amish M Patel
Ana Guardia
Christopher C Arico-Muendel
Christopher P Davie
Daniel Alvarez-Gómez
Emilio Alvarez-Ruíz
Esther Pérez-Herrán
Fátima Ortega-Muro
Gary K O'Donovan
P304
P3181
P356
10.1021/JM401326J
P407
P577
2014-02-27T00:00:00Z