Sequence conservation of apolipoprotein A-I affords novel insights into HDL structure-function
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Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-INew insights into the determination of HDL structure by apolipoproteins: Thematic review series: high density lipoprotein structure, function, and metabolismCrystal Structure of C-terminal Truncated Apolipoprotein A-I Reveals the Assembly of High Density Lipoprotein (HDL) by DimerizationThe effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in miceThe crystal structure of the C-terminal truncated apolipoprotein A-I sheds new light on amyloid formation by the N-terminal fragment.MD simulations suggest important surface differences between reconstituted and circulating spherical HDL.Arginine-directed glycation and decreased HDL plasma concentration and functionalityConformational and aggregation properties of the 1-93 fragment of apolipoprotein A-I.An experimentally robust model of monomeric apolipoprotein A-I created from a chimera of two X-ray structures and molecular dynamics simulationsAnti-inflammatory mechanisms of apolipoprotein A-I mimetic peptide in acute respiratory distress syndrome secondary to sepsis.Cations form sequence selective motifs within DNA grooves via a combination of cation-pi and ion-dipole/hydrogen bond interactions."Sticky" and "promiscuous", the yin and yang of apolipoprotein A-I termini in discoidal high-density lipoproteins: a combined computational-experimental approach.Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL.Impact of HDL oxidation by the myeloperoxidase system on sterol efflux by the ABCA1 pathwayThe role of factor XIa (FXIa) catalytic domain exosite residues in substrate catalysis and inhibition by the Kunitz protease inhibitor domain of protease nexin 2Impact of self-association on function of apolipoprotein A-ICubbing in proapolipoprotein maturation.Site-specific oxidation of apolipoprotein A-I impairs cholesterol export by ABCA1, a key cardioprotective function of HDL.Sidedness of interfacial arginine residues and anti-atherogenicity of apolipoprotein A-I mimetic peptidesValidation of previous computer models and MD simulations of discoidal HDL by a recent crystal structure of apoA-I.Small-angle X-ray scattering of the cholesterol incorporation into human ApoA1-POPC discoidal particlesCrystal structure of Δ(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoilLipid complex of apolipoprotein A-I mimetic peptide 4F is a novel platform for paraoxonase-1 binding and enhancing its activity and stability.Rotational and hinge dynamics of discoidal high density lipoproteins probed by interchain disulfide bond formationFolded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis.Molecules that mimic apolipoprotein A-I: potential agents for treating atherosclerosis.Proteolysis of apolipoprotein A-I by secretory phospholipase A₂: a new link between inflammation and atherosclerosisApolipoprotein A-I and A-I mimetic peptides: a role in atherosclerosisRole of apolipoprotein A-II in the structure and remodeling of human high-density lipoprotein (HDL): protein conformational ensemble on HDL.High-density lipoprotein, mitochondrial dysfunction and cell survival mechanisms.ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease.Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I.Antioxidative activity of high-density lipoprotein (HDL): Mechanistic insights into potential clinical benefit.Plasminogen promotes cholesterol efflux by the ABCA1 pathway.The secondary structure of apolipoprotein A-I on 9.6-nm reconstituted high-density lipoprotein determined by EPR spectroscopy.Self-assembling peptides form nanodiscs that stabilize membrane proteins.High-Density Lipoprotein Regulation of Mitochondrial Function.Chymase released from hypoxia-activated cardiac mast cells cleaves human apolipoproteinA-I at Tyr192 and compromises its cardioprotective activity.
P2860
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P2860
Sequence conservation of apolipoprotein A-I affords novel insights into HDL structure-function
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Sequence conservation of apoli ...... ts into HDL structure-function
@ast
Sequence conservation of apoli ...... ts into HDL structure-function
@en
Sequence conservation of apoli ...... s into HDL structure-function.
@nl
type
label
Sequence conservation of apoli ...... ts into HDL structure-function
@ast
Sequence conservation of apoli ...... ts into HDL structure-function
@en
Sequence conservation of apoli ...... s into HDL structure-function.
@nl
prefLabel
Sequence conservation of apoli ...... ts into HDL structure-function
@ast
Sequence conservation of apoli ...... ts into HDL structure-function
@en
Sequence conservation of apoli ...... s into HDL structure-function.
@nl
P2093
P2860
P356
P1476
Sequence conservation of apoli ...... ts into HDL structure-function
@en
P2093
Anantharamaiah GM
Bashtovyy D
Segrest JP
P2860
P304
P356
10.1194/JLR.R012658
P577
2011-03-01T00:00:00Z