Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
about
The structural basis for receptor recognition of human interleukin-18IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis.Distinct expression of interleukin (IL)-36α, β and γ, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease.Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist.IL-36γ has proinflammatory effects on human endothelial cells.Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis.IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor.Structural and Functional Attributes of the Interleukin-36 Receptor.The family of the interleukin-1 receptors.Regulation and function of interleukin-36 cytokines.Quantitative ligand and receptor binding studies reveal the mechanism of interleukin-36 (IL-36) pathway activation.The severity of imiquimod-induced mouse skin inflammation is independent of endogenous IL-38 expression.Homodimerization attenuates the anti-inflammatory activity of interleukin-37
P2860
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P2860
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
@ast
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
@en
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
@nl
type
label
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
@ast
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
@en
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
@nl
prefLabel
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
@ast
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
@en
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
@nl
P3181
P356
P1476
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
@en
P2093
Eric J Sundberg
Sebastian Günther
P304
P3181
P356
10.4049/JIMMUNOL.1400538
P407
P577
2014-07-15T00:00:00Z