Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
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G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRsStructural Studies of G Protein-Coupled ReceptorsLandmark studies on the glucagon subfamily of GPCRs: from small molecule modulators to a crystal structurePost-expression strategies for structural investigations of membrane proteins.Large-scale production and protein engineering of G protein-coupled receptors for structural studiesStructure and ligand-binding mechanism of the human OX1 and OX2 orexin receptorsUsing the fragment molecular orbital method to investigate agonist-orexin-2 receptor interactionsAntibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2.Peptide ligand recognition by G protein-coupled receptorsModeling of the OX1R-orexin-A complex suggests two alternative binding modes.From G Protein-coupled Receptor Structure Resolution to Rational Drug Design.Molecular Insights into the Transmembrane Domain of the Thyrotropin ReceptorOpioid receptors: Structural and mechanistic insights into pharmacology and signaling.Crucial role of the orexin-B C-terminus in the induction of OX1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis.New paradigms in GPCR drug discovery.Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region.Clinical Sleep-Wake Disorders II: Focus on Insomnia and Circadian Rhythm Sleep Disorders.Challenges in the development of therapeutics for narcolepsy.Current strategies for protein production and purification enabling membrane protein structural biology.Homology-based Modeling of Rhodopsin-like Family Members in the Inactive State: Structural Analysis and Deduction of Tips for Modeling and Optimization.Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models.Structural studies of G protein-coupled receptors.β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop.Application of GPCR Structures for Modelling of Free Fatty Acid Receptors.New approaches towards the understanding of integral membrane proteins: A structural perspective on G protein-coupled receptors.How to Choose the Suitable Template for Homology Modelling of GPCRs: 5-HT7 Receptor as a Test Case.From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid.Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen AtomsHomology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracyOrexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics.7×7 RMSD matrix: A new method for quantitative comparison of the transmembrane domain structures in the G-protein coupled receptors.Orexin/Hypocretin Signaling.Increasing the Stability of Recombinant Human Green Cone Pigment.A Structural Framework for GPCR Chemogenomics: What's In a Residue Number?Orexin research: patent news from 2016.The Human Orexin/Hypocretin Receptor Crystal Structures.New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies.X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog.New techniques, applications and perspectives in neuropeptide research.
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P2860
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
description
2015 nî lūn-bûn
@nan
2015 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մարտին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
@ast
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
@en
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
@nl
type
label
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
@ast
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
@en
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
@nl
prefLabel
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
@ast
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
@en
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
@nl
P2860
P3181
P356
P1433
P1476
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
@en
P2093
Daniel M Rosenbaum
P2860
P2888
P304
P3181
P356
10.1038/NATURE14035
P407
P577
2015-03-12T00:00:00Z
P6179
1010459775