Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo
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Partially Saturated Bicyclic Heteroaromatics as an sp(3) -Enriched Fragment Collection.Crystal structure of 3,6,6-trimethyl-4-oxo-1-(pyridin-2-yl)-4,5,6,7-tetra-hydro-1H-indazol-7-aminium chloride and its monohydrate.A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles.Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
P2860
Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo
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2015 nî lūn-bûn
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2015 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Tetrahydroindazoles as Interle ...... macodynamic Modulation in Vivo
@ast
Tetrahydroindazoles as Interle ...... macodynamic Modulation in Vivo
@en
Tetrahydroindazoles as Interle ...... macodynamic Modulation in Vivo
@nl
type
label
Tetrahydroindazoles as Interle ...... macodynamic Modulation in Vivo
@ast
Tetrahydroindazoles as Interle ...... macodynamic Modulation in Vivo
@en
Tetrahydroindazoles as Interle ...... macodynamic Modulation in Vivo
@nl
prefLabel
Tetrahydroindazoles as Interle ...... macodynamic Modulation in Vivo
@ast
Tetrahydroindazoles as Interle ...... macodynamic Modulation in Vivo
@en
Tetrahydroindazoles as Interle ...... macodynamic Modulation in Vivo
@nl
P2093
P356
P1476
Tetrahydroindazoles as Interle ...... macodynamic Modulation in Vivo
@en
P2093
Ali A Zarrin
Claire Ellebrandt
Daniel B Stein
Daniel F Ortwine
Daniel Kordt
Jason D Burch
John J Barker
Kathy Barrett
P304
P356
10.1021/JM501998M
P407
P577
2015-05-14T00:00:00Z