Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys
about
Targeting Steroidogenic Cytochromes P450 (CYPs) with 6-Substituted 1-Imidazolylmethylxanthones.Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2).The potential of targeting CYP11B.Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors.N-Aryl-7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido-[3,2,1-ij]quinoline-6-carboxamides. The Synthesis and Effects on Urinary Output.Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.
P2860
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys
description
2015 nî lūn-bûn
@nan
2015 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Discovery of 4-Aryl-5,6,7,8-te ...... Rodents and Cynomolgus Monkeys
@ast
Discovery of 4-Aryl-5,6,7,8-te ...... Rodents and Cynomolgus Monkeys
@en
Discovery of 4-Aryl-5,6,7,8-te ...... Rodents and Cynomolgus Monkeys
@nl
type
label
Discovery of 4-Aryl-5,6,7,8-te ...... Rodents and Cynomolgus Monkeys
@ast
Discovery of 4-Aryl-5,6,7,8-te ...... Rodents and Cynomolgus Monkeys
@en
Discovery of 4-Aryl-5,6,7,8-te ...... Rodents and Cynomolgus Monkeys
@nl
prefLabel
Discovery of 4-Aryl-5,6,7,8-te ...... Rodents and Cynomolgus Monkeys
@ast
Discovery of 4-Aryl-5,6,7,8-te ...... Rodents and Cynomolgus Monkeys
@en
Discovery of 4-Aryl-5,6,7,8-te ...... Rodents and Cynomolgus Monkeys
@nl
P2093
P1476
Discovery of 4-Aryl-5,6,7,8-te ...... Rodents and Cynomolgus Monkeys
@en
P2093
Alexander V Mayweg
André M Alker
Benoit Hornsperger
Bernd Kuhn
Dominique Burger
Giorgio Ottaviani
Hans Peter Märki
Hans-Jakob Krebs
Johannes D Aebi
Kurt Amrein
P304
P356
10.1021/ACS.JMEDCHEM.5B00851
P407
P577
2015-10-22T00:00:00Z