Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

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http://www.wikidata.org/entity/Q27703506
BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.Drug Discovery Targeting Bromodomain-Containing Protein 4.NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compoundsClinical trials for BET inhibitors run ahead of the science.BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.BET inhibitors in cancer therapeutics: a patent review.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Structural features and inhibitors of bromodomains.A theoretical insight into selectivity of inhibitors toward two domains of bromodomain-containing protein 4 using molecular dynamics simulations.Pharmacophore-based virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation for the discovery of novel BRD4 inhibitors.Deciphering the mechanisms of selective inhibition for the tandem BD1/BD2 in the BET-bromodomain family.Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition.The BET inhibitor I-BET762 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine.
P2860

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

Item
http://www.wikidata.org/entity/Q27703506
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Exploring Selective Inhibition ...... terminal Domain (BET) Proteins
@ast
Exploring Selective Inhibition ...... terminal Domain (BET) Proteins
@en
Exploring Selective Inhibition ...... terminal Domain (BET) Proteins
@nl
type
label
Exploring Selective Inhibition ...... terminal Domain (BET) Proteins
@ast
Exploring Selective Inhibition ...... terminal Domain (BET) Proteins
@en
Exploring Selective Inhibition ...... terminal Domain (BET) Proteins
@nl
prefLabel
Exploring Selective Inhibition ...... terminal Domain (BET) Proteins
@ast
Exploring Selective Inhibition ...... terminal Domain (BET) Proteins
@en
Exploring Selective Inhibition ...... terminal Domain (BET) Proteins
@nl
P1433
P1476
P2093
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P3181
P356
P1433
P1476
Exploring Selective Inhibition ...... terminal Domain (BET) Proteins
@en
P2093
P304
P31
P3181
P356
10.1021/ACS.JMEDCHEM.5B01708
P407
P433
P478
P50
P577
P698