Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
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Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survivalA Chimeric ATP-Linked Nucleotide Enables Luminescence Signaling of Damage Surveillance by MTH1, a Cancer Target.Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.Validation and development of MTH1 inhibitors for treatment of cancer.Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.MTH1 as a Chemotherapeutic Target: The Elephant in the Room.The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells.Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma.Oxidative guanine base damage regulates human telomerase activity.Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable LiabilityNon-kinase targets of protein kinase inhibitors.2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway(S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1.Exploiting DNA repair defects for novel cancer therapies.The role of miR-485-5p/NUDT1 axis in gastric cancer.Farnesyl phenolic enantiomers as natural MTH1 inhibitors from Ganoderma sinense.Computational Macrocyclization: From de novo Macrocycle Generation to Binding Affinity Estimation.MutT-related proteins are novel progression and prognostic markers for colorectal cancer.TH588, an MTH1 inhibitor, enhances phenethyl isothiocyanate-induced growth inhibition in pancreatic cancer cells.Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma
P2860
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P2860
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
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2016 nî lūn-bûn
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2016 թուականի Մարտին հրատարակուած գիտական յօդուած
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2016 թվականի մարտին հրատարակված գիտական հոդված
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2016年の論文
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2016年論文
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2016年論文
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2016年論文
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2016年論文
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2016年論文
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2016年论文
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name
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
@ast
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
@en
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
@nl
type
label
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
@ast
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
@en
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
@nl
prefLabel
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
@ast
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
@en
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
@nl
P2093
P50
P3181
P1476
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
@en
P2093
Ben Taylor
David R Jones
Graeme Walker
Husam Alwan
James S Scott
Jason Breed
Jason G Kettle
Kay Eckersley
P304
P3181
P356
10.1021/ACS.JMEDCHEM.5B01760
P407
P577
2016-02-16T00:00:00Z