Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
about
Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathwayA CRISPR toolbox to study virus-host interactionsThe changing landscape of membrane protein structural biology through developments in electron microscopy.Structure of the Ebola virus glycoprotein spike within the virion envelope at 11 Å resolution.Fighting Ebola: A Window for Vaccine Re-evaluation?Identification of a coumarin-based antihistamine-like small molecule as an anti-filoviral entry inhibitor.Clues to NPC1-mediated cholesterol export from lysosomes.Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export.Unravelling biological macromolecules with cryo-electron microscopy.Human Adaptation of Ebola Virus during the West African Outbreak.Genome sequencing in a case of Niemann-Pick type CIn vitro assembly of Ebola virus nucleocapsid-like complex expressed in E. coliTriazoles inhibit cholesterol export from lysosomes by binding to NPC1.Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage.3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.Common structural features of cholesterol binding sites in crystallized soluble proteins.The roles of ebolavirus glycoproteins in viral pathogenesis.Electron Cryo-microscopy as a Tool for Structure-Based Drug Development.Interferon Control of the Sterol Metabolic Network: Bidirectional Molecular Circuitry-Mediating Host Protection.Routes and mechanisms of post-endosomal cholesterol trafficking: A story that never ends.Exacerbating and reversing lysosomal storage diseases: from yeast to humans.Biochemical Basis for Increased Activity of Ebola Glycoprotein in the 2013-16 Epidemic.Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic.Filovirus Structural Biology: The Molecules in the Machine.Ceramide Transport from the Endoplasmic Reticulum to the Trans Golgi Region at Organelle Membrane Contact Sites.Mechanisms of Filovirus Entry.Lipid metabolism fattens up hedgehog signaling.Concerted regulation of npc2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin.Energy coupling mechanisms of AcrB-like RND transporters.The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.The extending spectrum of NPC1-related human disorders: from Niemann-Pick C1 Disease to obesity.Emerging Roles for the Lysosome in Lipid Metabolism.High-content screen for modifiers of Niemann-Pick Type C disease in patient cells.Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor.Recent neuroimaging, neurophysiological, and neuropathological advances for the understanding of NPC.Association of NPC1 variant p.P237S with a pathogenic splice variant in two Niemann-Pick disease type C1 patients.Electron cryomicroscopy as a powerful tool in biomedical research.
P2860
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P2860
Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
description
2016 nî lūn-bûn
@nan
2016 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Structural Insights into the N ...... l Transfer and Ebola Infection
@ast
Structural Insights into the N ...... l Transfer and Ebola Infection
@en
Structural Insights into the N ...... l Transfer and Ebola Infection
@nl
type
label
Structural Insights into the N ...... l Transfer and Ebola Infection
@ast
Structural Insights into the N ...... l Transfer and Ebola Infection
@en
Structural Insights into the N ...... l Transfer and Ebola Infection
@nl
prefLabel
Structural Insights into the N ...... l Transfer and Ebola Infection
@ast
Structural Insights into the N ...... l Transfer and Ebola Infection
@en
Structural Insights into the N ...... l Transfer and Ebola Infection
@nl
P2093
P50
P921
P3181
P1433
P1476
Structural Insights into the N ...... l Transfer and Ebola Infection
@en
P2093
George F Gao
Hongwu Qian
Jianping Wu
Peiyi Wang
Pingping Cao
Qiang Zhou
Weiyun Huang
P304
P3181
P356
10.1016/J.CELL.2016.05.022
P407
P577
2016-06-02T00:00:00Z