Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength
about
Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.A covalent antagonist for the human adenosine A2A receptor.Mapping the allosteric sites of the A2A adenosine receptor.A systematic analysis of atomic protein-ligand interactions in the PDB.Structure-Affinity Relationships and Structure-Kinetic Relationships of 1,2-Diarylimidazol-4-carboxamide Derivatives as Human Cannabinoid 1 Receptor Antagonists.Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation.Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals.Impact of protein-ligand solvation and desolvation on transition state thermodynamic properties of adenosine A2A ligand binding kinetics.Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor.Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases.Identification of Two New Cholesterol Interaction Sites on the A2A Adenosine Receptor.Molecular Basis of Ligand Dissociation from G Protein-Coupled Receptors and Predicting Residence Time.A Structural Framework for GPCR Chemogenomics: What's In a Residue Number?Breakthrough in GPCR Crystallography and Its Impact on Computer-Aided Drug Design.Current and Future Challenges in GPCR Drug Discovery.A binding kinetics study of human adenosine A3 receptor agonists.Supporting the Identification of Novel Fragment-Based Positive Allosteric Modulators Using a Supervised Molecular Dynamics Approach: A Retrospective Analysis Considering the Human A2A Adenosine Receptor as a Key Example.Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins.In silico studies targeting G-protein coupled receptors for drug research against Parkinson's disease.Prediction of consensus binding mode geometries for related chemical series of positive allosteric modulators of adenosine and muscarinic acetylcholine receptors.Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein.G protein-coupled receptors: the evolution of structural insight.
P2860
Q41052019-0BD2923E-8702-4D2F-A338-D64C75508EA8Q41763691-28B19938-4C99-494F-A930-3C6C33E021EFQ46049863-DD7F2B66-FFC9-4A50-B990-4B743ACC7FE1Q47098164-76A26667-A22F-4A18-BD55-F5DE02A050BFQ47103408-D135D51C-0E39-413E-BC19-0374DB5CB14BQ47194737-4576F74B-8D4C-45CF-9E64-8BCBFA22A693Q47222471-41901346-F01B-40A5-A1E0-DDB586743A3CQ47225761-C9660426-3293-4B1A-A38A-29BFC43899E1Q47228564-06BC9E2B-E51B-4388-90BE-13A4CA4E513EQ47242194-51956E39-B13D-4D6F-9A9F-D2A0161FEFD9Q47323511-74779DDA-B6F6-4705-A85C-31D73E7001ACQ47348698-CBDC32A9-A63E-4B60-BD27-E86C8EA9CAA2Q47348737-5134C1BD-F714-48DF-9D7B-43FEF229996BQ47348749-3FF1D2FA-450B-4E78-B284-3DBC69B49369Q47348761-CC636127-66D5-40D4-9081-2DC1C9823726Q47804733-1C171131-E8E0-4EB8-B3DB-B64529B2ABB1Q50641788-022D2AA2-E719-47AE-A774-EB687FC98FFCQ52338934-04978877-1FDB-4299-91ED-8B6333D0CFC6Q52369966-A9DAC84C-BE4E-4D75-A4B9-9AD2DCC26973Q52665081-6CC856A5-3C65-490D-88E6-67ED8FAB08A7Q52737158-C430B855-EFDE-4AE5-A7DE-7ED5DA9EE620Q55072103-F4BD57A4-E0F5-49ED-AC56-C04FBC9B4442Q55278334-DF9B46AB-4248-4C9F-B2CD-F5E0DF24CD74
P2860
Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength
description
2016 nî lūn-bûn
@nan
2016 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Controlling the Dissociation o ...... lation of Salt Bridge Strength
@ast
Controlling the Dissociation o ...... lation of Salt Bridge Strength
@en
Controlling the Dissociation o ...... lation of Salt Bridge Strength
@nl
type
label
Controlling the Dissociation o ...... lation of Salt Bridge Strength
@ast
Controlling the Dissociation o ...... lation of Salt Bridge Strength
@en
Controlling the Dissociation o ...... lation of Salt Bridge Strength
@nl
prefLabel
Controlling the Dissociation o ...... lation of Salt Bridge Strength
@ast
Controlling the Dissociation o ...... lation of Salt Bridge Strength
@en
Controlling the Dissociation o ...... lation of Salt Bridge Strength
@nl
P2093
P50
P1476
Controlling the Dissociation o ...... lation of Salt Bridge Strength
@en
P2093
Andrea Bortolato
Andrew S Doré
Elena Segala
Francesca Deflorian
James C Errey
Robert K Y Cheng
Robert M Cooke
P304
P356
10.1021/ACS.JMEDCHEM.6B00653
P407
P577
2016-07-14T00:00:00Z