Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation
about
"Wait anaphase" signals are not confined to the mitotic spindle.Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.Dynamic ubiquitin signaling in cell cycle regulation.The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.Delayed APC/C activation extends the first mitosis of mouse embryos.Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C.Basis of catalytic assembly of the mitotic checkpoint complex.Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint ArrestA sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling.BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling.Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation.The PP2AB56 phosphatase promotes the association of Cdc20 with APC/C in mitosis.Role of ubiquitylation of components of mitotic checkpoint complex in their dissociation from anaphase-promoting complex/cyclosome.Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis.Sumoylation promotes optimal APC/C Activation and Timely Anaphase.USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability.MAD1: Kinetochore Receptors and Catalytic Mechanisms.TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCCImplications of alternative routes to APC/C inhibition by the mitotic checkpoint complex
P2860
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P2860
Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation
description
2016 nî lūn-bûn
@nan
2016 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Cryo-EM of Mitotic Checkpoint ...... gulation of Ubiquitin Ligation
@ast
Cryo-EM of Mitotic Checkpoint ...... gulation of Ubiquitin Ligation
@en
Cryo-EM of Mitotic Checkpoint ...... gulation of Ubiquitin Ligation
@nl
type
label
Cryo-EM of Mitotic Checkpoint ...... gulation of Ubiquitin Ligation
@ast
Cryo-EM of Mitotic Checkpoint ...... gulation of Ubiquitin Ligation
@en
Cryo-EM of Mitotic Checkpoint ...... gulation of Ubiquitin Ligation
@nl
prefLabel
Cryo-EM of Mitotic Checkpoint ...... gulation of Ubiquitin Ligation
@ast
Cryo-EM of Mitotic Checkpoint ...... gulation of Ubiquitin Ligation
@en
Cryo-EM of Mitotic Checkpoint ...... gulation of Ubiquitin Ligation
@nl
P2093
P2860
P50
P3181
P1433
P1476
Cryo-EM of Mitotic Checkpoint ...... gulation of Ubiquitin Ligation
@en
P2093
Holger Stark
Jan-Michael Peters
Prakash Dube
Renping Qiao
Ryan VanderLinden
Sachdev S Sidhu
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2016.07.003
P577
2016-08-10T00:00:00Z