Enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles
about
N- and C-capping preferences for all 20 amino acids in alpha-helical peptidesStructure of a protein G helix variant suggests the importance of helix propensity and helix dipole interactions in protein designLong-distance conformational changes in a protein engineered by modulated sequence duplicationStereoelectronic and steric effects in side chains preorganize a protein main chainStructure of the YajR transporter suggests a transport mechanism based on the conserved motif AStructural basis of increased resistance to thermal denaturation induced by single amino acid substitution in the sequence of beta-glucosidase A from Bacillus polymyxaHyperthermophilic enzymes: sources, uses, and molecular mechanisms for thermostabilityA network representation of protein structures: implications for protein stability.Thermostability of in vitro evolved Bacillus subtilis lipase A: a network and dynamics perspective.3D deep convolutional neural networks for amino acid environment similarity analysisEffects of salt bridges on protein structure and design.Analysis of the dynamics of rhizomucor miehei lipase at different temperatures.Helix-stabilizing effects of the pentapeptide KIFMK and its related peptides on the sodium channel inactivation gate peptides.On the orientation of the backbone dipoles in native foldsBackbone dipoles generate positive potentials in all proteins: origins and implications of the effectTopological distribution of four-alpha-helix bundlesDesign and creation of a Ca2+ binding site in human lysozyme to enhance structural stability.Dominant role of local dipoles in stabilizing uncompensated charges on a sulfate sequestered in a periplasmic active transport proteinAmino acid properties conserved in molecular evolution.Engineering Proteins for Thermostability with iRDP Web ServerDifferences in the amino acid distributions of 3(10)-helices and alpha-helices.The sequence of a subtilisin-type protease (aerolysin) from the hyperthermophilic archaeum Pyrobaculum aerophilum reveals sites important to thermostabilityDesign and structural analysis of an engineered thermostable chicken lysozyme.Primary structure elements responsible for the conformational switch in the envelope glycoprotein gp120 from human immunodeficiency virus type 1: LPCR is a motif governing folding.Thermal adaptation analyzed by comparison of protein sequences from mesophilic and extremely thermophilic Methanococcus speciesPosition dependence of the 13C chemical shifts of alpha-helical model peptides. Fingerprint of the 20 naturally occurring amino acids.Charged histidine affects alpha-helix stability at all positions in the helix by interacting with the backbone chargesAspartate transcarbamylase from the deep-sea hyperthermophilic archaeon Pyrococcus abyssi: genetic organization, structure, and expression in Escherichia coli.Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organismsCore structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation.Dipoles localized at helix termini of proteins stabilize charges.Experimental and Computational Analysis of Protein Stabilization by Gly-to-d-Ala Substitution: A Convolution of Native State and Unfolded State Effects.Intragenic suppressors of induction-deficient TetR mutants: localization and potential mechanism of action.Further stabilization of 3-isopropylmalate dehydrogenase of an extreme thermophile, Thermus thermophilus, by a suppressor mutation method.Repurposing a bacterial quality control mechanism to enhance enzyme production in living cellsAutoinhibition of ETV6 DNA Binding Is Established by the Stability of Its Inhibitory Helix.Peptide rescue of an N-terminal truncation of the Stoffel fragment of taq DNA polymerase.Amino acid substitutions enhancing thermostability of Bacillus polymyxa beta-glucosidase AEffect of a single aspartate on helix stability at different positions in a neutral alanine-based peptide.Oligomeric integrity--the structural key to thermal stability in bacterial alcohol dehydrogenases.
P2860
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P2860
Enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles
description
1988 nî lūn-bûn
@nan
1988 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
name
Enhanced protein thermostabili ...... eract with alpha-helix dipoles
@ast
Enhanced protein thermostabili ...... eract with alpha-helix dipoles
@en
Enhanced protein thermostabili ...... eract with alpha-helix dipoles
@nl
type
label
Enhanced protein thermostabili ...... eract with alpha-helix dipoles
@ast
Enhanced protein thermostabili ...... eract with alpha-helix dipoles
@en
Enhanced protein thermostabili ...... eract with alpha-helix dipoles
@nl
prefLabel
Enhanced protein thermostabili ...... eract with alpha-helix dipoles
@ast
Enhanced protein thermostabili ...... eract with alpha-helix dipoles
@en
Enhanced protein thermostabili ...... eract with alpha-helix dipoles
@nl
P2093
P356
P1433
P1476
Enhanced protein thermostabili ...... eract with alpha-helix dipoles
@en
P2093
B W Matthews
H Nicholson
W J Becktel
P2888
P356
10.1038/336651A0
P407
P577
1988-12-15T00:00:00Z
P6179
1026938262