Crystal structure of human dihydrofolate reductase complexed with folate
about
Significant hydrogen exchange protection in GroEL-bound DHFR is maintained during iterative rounds of substrate cyclingHidden localization motifs: naturally occurring peroxisomal targeting signals in non-peroxisomal proteinsPhylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthaseThe sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzymeMultiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate ResistanceFunctional Role for the Conformationally Mobile Phenylalanine 223 in the Reaction of Methylenetetrahydrofolate Reductase from Escherichia coliPreferential selection of isomer binding from chiral mixtures: alternate binding modes observed for theEandZisomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductaseBiological and Structural Evaluation of 10 R - and 10 S -Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide TransformylaseStructural genomics for drug design against the pathogen Coxiella burnetiiX-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complexInterpretable correlation descriptors for quantitativestructure-activity relationshipsIsolation of rat dihydrofolate reductase gene and characterization of recombinant enzymeDicyclic and tricyclic diaminopyrimidine derivatives as potent inhibitors of Cryptosporidium parvum dihydrofolate reductase: structure-activity and structure-selectivity correlationsStructural trees for protein superfamilies.Tobacco budworm dihydrofolate reductase is a promising target for insecticide discovery.Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.Effects of fluorine substitution on the structure and dynamics of complexes of dihydrofolate reductase (Escherichia coli).Yop fusions to tightly folded protein domains and their effects on Yersinia enterocolitica type III secretion.Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance.Native-like structure of a protein-folding intermediate bound to the chaperonin GroEL.Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments.Folding trajectories of human dihydrofolate reductase inside the GroEL GroES chaperonin cavity and free in solution.Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.Unfolding of preproteins upon import into mitochondria.Substrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry.Classification of ligand molecules in PDB with graph match-based structural superposition.Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?Structural analysis of dihydrofolate reductases enables rationalization of antifolate binding affinities and suggests repurposing possibilities.Pharmacoinformatic Study on the Selective Inhibition of the Protozoan Dihydrofolate Reductase Enzymes.The crystal structure of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveals a novel architecture for the bifunctional enzyme.Virtual screening, docking, and dynamics of potential new inhibitors of dihydrofolate reductase from Yersinia pestis.Molecular modeling studies of Yersinia pestis dihydrofolate reductase.Quantum mechanics implementation in drug-design workflows: does it really help?3H-n.m.r. studies of multiple conformations and dynamic processes in complexes of folate and methotrexate with Lactobacillus casei dihydrofolate reductaseStudy on Folate Binding Domain of Dihydrofolate Reductase in Different Plant species and Human beings.A comparative molecular docking study of curcumin and methotrexate to dihydrofolate reductase.Activation mechanism and modification kinetics of Chinese hamster dihydrofolate reductase by p-chloromercuribenzoate.High-throughput sample preparation for protein or peptide structural characterization.Analysis of a conditional degradation signal in yeast and mammalian cells.Insight into the molecular mechanism about lowered dihydrofolate binding affinity to dihydrofolate reductase-like 1 (DHFRL1).
P2860
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P2860
Crystal structure of human dihydrofolate reductase complexed with folate
description
1988 nî lūn-bûn
@nan
1988 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
name
Crystal structure of human dihydrofolate reductase complexed with folate
@ast
Crystal structure of human dihydrofolate reductase complexed with folate
@en
Crystal structure of human dihydrofolate reductase complexed with folate
@nl
type
label
Crystal structure of human dihydrofolate reductase complexed with folate
@ast
Crystal structure of human dihydrofolate reductase complexed with folate
@en
Crystal structure of human dihydrofolate reductase complexed with folate
@nl
prefLabel
Crystal structure of human dihydrofolate reductase complexed with folate
@ast
Crystal structure of human dihydrofolate reductase complexed with folate
@en
Crystal structure of human dihydrofolate reductase complexed with folate
@nl
P2093
P1433
P1476
Crystal structure of human dihydrofolate reductase complexed with folate
@en
P2093
P2860
P304
P356
10.1111/J.1432-1033.1988.TB14108.X
P407
P577
1988-06-01T00:00:00Z