Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase
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Probing stereoselective inhibition of the acyl binding site of cholesterol esterase with four diastereomers of 2'-N-alpha-methylbenzylcarbamyl-1, 1'-bi-2-naphthol.Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interestCrystal structure of the catalytic domain of human bile salt activated lipaseCrystal structure of the open form of dog gastric lipase in complex with a phosphonate inhibitorA substrate-induced switch in the reaction mechanism of a thermophilic esterase: kinetic evidences and structural basisThe structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolismCrystal structure of a secreted lipase from Gibberella zeae reveals a novel “double-lock” mechanismDifferent active-site loop orientation in serine hydrolases versus acyltransferasesSubstrate tunnels in enzymes: structure-function relationships and computational methodologyModelling substrate specificity and enantioselectivity for lipases and esterases by substrate-imprinted docking.Functional characteristics of the oxyanion hole in human acetylcholinesterase.Structure-function relationships of hormone-sensitive lipase.Uncovering divergent evolution of α/β-hydrolases: a surprising residue substitution needed to convert Hevea brasiliensis hydroxynitrile lyase into an esteraseDistant homology modeling of LCAT and its validation through in silico targeting and in vitro and in vivo assaysCounteraction of Trehalose on N, N-Dimethylformamide-Induced Candida rugosa Lipase Denaturation: Spectroscopic Insight and Molecular Dynamic Simulation.Enzyme Tunnels and Gates As Relevant Targets in Drug Design.A structural basis for enantioselective inhibition of Candida rugosa lipase by long-chain aliphatic alcoholsMutants provide evidence of the importance of glycosydic chains in the activation of lipase 1 from Candida rugosa.The Lid Domain in Lipases: Structural and Functional Determinant of Enzymatic Properties.Effects of surfactants on lipase structure, activity, and inhibition.Multiple mutagenesis of non-universal serine codons of the Candida rugosa LIP2 gene and biochemical characterization of purified recombinant LIP2 lipase overexpressed in Pichia pastoris.Molecular modeling of the enantioselectivity in lipase-catalyzed transesterification reactions.Structural determinants defining common stereoselectivity of lipases toward secondary alcohols.Molecular modeling of the structures of human and rat pancreatic cholesterol esterases.Computer modeling of substrate binding to lipases from Rhizomucor miehei, Humicola lanuginosa, and Candida rugosa.Enantioselectivity of recombinant Rhizomucor miehei lipase in the ring opening of oxazolin-5(4H)-ones.A cleft type receptor which combines an oxyanion hole with electrostatic interactions.Homology modelling and molecular dynamics aided analysis of ligand complexes demonstrates functional properties of lipid-transfer proteins encoded by the barley low-temperature-inducible gene family, blt4.Revealing the Roles of Subdomains in the Catalytic Behavior of Lipases/Acyltransferases Homologous to CpLIP2 through Rational Design of Chimeric Enzymes.Quantitative structure-activity relationship correlation between molecular structure and the Rayleigh enantiomeric enrichment factor.Design of hyperthermophilic lipase chimeras by key motif-directed recombination.A mixed molecular modeling-robotics approach to investigate lipase large molecular motions.New insights in the activation of human cholesterol esterase to design potent anti-cholesterol drugs.Altering the scissile fatty acid binding site ofCandida antarcticalipase A by protein engineering for the selective hydrolysis of medium chain fatty acids
P2860
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P2860
Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase
description
1994 nî lūn-bûn
@nan
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Analogs of reaction intermedia ...... site in Candida rugosa lipase
@ast
Analogs of reaction intermedia ...... site in Candida rugosa lipase
@en
Analogs of reaction intermedia ...... site in Candida rugosa lipase
@nl
type
label
Analogs of reaction intermedia ...... site in Candida rugosa lipase
@ast
Analogs of reaction intermedia ...... site in Candida rugosa lipase
@en
Analogs of reaction intermedia ...... site in Candida rugosa lipase
@nl
prefLabel
Analogs of reaction intermedia ...... site in Candida rugosa lipase
@ast
Analogs of reaction intermedia ...... site in Candida rugosa lipase
@en
Analogs of reaction intermedia ...... site in Candida rugosa lipase
@nl
P2093
P3181
P356
P1433
P1476
Analogs of reaction intermedia ...... site in Candida rugosa lipase
@en
P2093
A N Serreqi
F Bouthillier
J D Schrag
P Grochulski
P304
P3181
P356
10.1021/BI00178A005
P407
P577
1994-03-01T00:00:00Z