Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
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Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosisGenetic counseling for FTD/ALS caused by the C9ORF72 hexanucleotide expansionSOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALSProtein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptideThe copper chaperone CCS directly interacts with copper/zinc superoxide dismutaseThe copper chaperone for superoxide dismutaseEffects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transportContribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysisOverexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injuryFamilial amyotrophic lateral sclerosis/motor neurone disease (FALS): a review of current developmentsThe Silver syndrome variant of hereditary spastic paraplegia maps to chromosome 11q12-q14, with evidence for genetic heterogeneity within this subtypeDisulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model miceOlesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosisMutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementiaAutophagy, mitochondria and oxidative stress: cross-talk and redox signallingStructures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosisMisfolded CuZnSOD and amyotrophic lateral sclerosisGenotype-phenotype correlations of amyotrophic lateral sclerosisUltrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesisEndoplasmic Reticulum Stress Interacts With Inflammation in Human DiseasesTherapeutic neuroprotective agents for amyotrophic lateral sclerosisMutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant miceMolecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutaseStructural Characterization of Zinc-deficient Human Superoxide Dismutase and Implications for ALSSuperoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosisStructural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q †Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93ADisrupted Zinc-Binding Sites in Structures of Pathogenic SOD1 Variants D124V and H80RStructures of mouse SOD1 and human/mouse SOD1 chimerasStructural switching of Cu,Zn-superoxide dismutases at loop VI: insights from the crystal structure of 2-mercaptoethanol-modified enzymeStructural Consequences of Cysteinylation of Cu/Zn-Superoxide DismutaseInhibitory synaptic regulation of motoneurons: a new target of disease mechanisms in amyotrophic lateral sclerosis.Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutaseComputational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutaseThe ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicitySuppression of oxidative damage by Saccharomyces cerevisiae ATX2, which encodes a manganese-trafficking protein that localizes to Golgi-like vesicles.The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activityHohenheim consensus workshop: copperApoptosis in the pathogenesis and treatment of diseaseThe complex molecular biology of amyotrophic lateral sclerosis (ALS)
P2860
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P2860
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
description
1993 nî lūn-bûn
@nan
1993 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
@ast
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
@en
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
@nl
type
label
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
@ast
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
@en
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
@nl
prefLabel
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
@ast
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
@en
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
@nl
P2093
P3181
P356
P1433
P1476
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
@en
P2093
A Cayabyab
B Herzfeldt
E D Getzoff
J A Tainer
P304
P3181
P356
10.1126/SCIENCE.8351519
P407
P577
1993-08-20T00:00:00Z