Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
about
A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3Potassium channel modulation by a toxin domain in matrix metalloprotease 23K+ channels as targets for specific immunomodulationEngineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytesComputational Studies of Venom Peptides Targeting Potassium ChannelsBioactive Mimetics of Conotoxins and other Venom PeptidesComputational studies of marine toxins targeting ion channelskappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivityStructures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domainNative Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High-Resolution X-ray Structure of ShK Toxin by Racemic Protein CrystallographyStructural Similarity between Defense Peptide from Wheat and Scorpion Neurotoxin Permits Rational Functional DesignKv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseasesStructural basis for antimicrobial activity of lasiocepsinModeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cyclesThe D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferationStructural and functional characterization of ryanodine receptor-natrin toxin interactionA family of secreted mucins from the parasitic nematode Toxocara canis bears diverse mucin domains but shares similar flanking six-cysteine repeat motifs.Genomic structure of a potassium channel toxin from Heteractis magnifica.Transcripts analysis of the entomopathogenic nematode Steinernema carpocapsae induced in vitro with insect haemolymph.Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity.Natural products and ion channel pharmacologyA novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes.Diversity of folds in animal toxins acting on ion channels.Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a K+ channel inhibitor-like fold.Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity.Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics.Conformational flexibility in the binding surface of the potassium channel blocker ShK.Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK.The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression.N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.Modeling the binding of three toxins to the voltage-gated potassium channel (Kv1.3)Kv Channel S1-S2 Linker Working as a Binding Site of Human β-Defensin 2 for Channel Activation Modulation.The evolutionary emergence of cell type-specific genes inferred from the gene expression analysis of Hydra.Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseasesAnalogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases.Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteriaDesigner and natural peptide toxin blockers of the KcsA potassium channel identified by phage displayThe Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune DiseasesBiochemical and electrophysiological characterization of two sea anemone type 1 potassium toxins from a geographically distant population of Bunodosoma caissarum.Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel
P2860
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P2860
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
description
1996 nî lūn-bûn
@nan
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
@ast
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
@en
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
@nl
type
label
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
@ast
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
@en
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
@nl
prefLabel
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
@ast
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
@en
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
@nl
P2093
P3181
P356
P1476
Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone
@en
P2093
M W Pennington
P K Pallaghy
R S Norton
P2860
P2888
P304
P3181
P356
10.1038/NSB0496-317
P407
P577
1996-04-01T00:00:00Z
P5875
P6179
1004607582