Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences
about
Human UDP-α-D-xylose synthase and Escherichia coli ArnA conserve a conformational shunt that controls whether xylose or 4-keto-xylose is producedA new model for protein stereospecificityAccurate protein crystallography at ultra-high resolution: valence electron distribution in crambinThe x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenationToward a quantum-mechanical description of metal-assisted phosphoryl transfer in pyrophosphataseCrystallographic Snapshot of a Productive Glycosylasparaginase–Substrate ComplexThe putative catalytic bases have, at most, an accessory role in the mechanism of arginine kinaseCrystal structure of the monomeric isocitrate dehydrogenase in the presence of NADP+: insight into the cofactor recognition, catalysis, and evolutionCrystal structure of Escherichia coli PdxA, an enzyme involved in the pyridoxal phosphate biosynthesis pathwayCrystal structure of the bifunctional chorismate synthase from Saccharomyces cerevisiaeThe role of phosphagen specificity loops in arginine kinaseThe structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptidesKinetic and X-Ray Structural Evidence for Negative Cooperativity in Substrate Binding to Nicotinate Mononucleotide Adenylyltransferase (NMAT) from Bacillus anthracisCrystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme InactivationGeometric Restraint Drives On- and Off-pathway Catalysis by the Escherichia coli Menaquinol:Fumarate ReductaseInduced Fit and the Catalytic Mechanism of Isocitrate DehydrogenaseStructure of a highly NADP+-specific isocitrate dehydrogenaseCrystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombeNovel complex MAD phasing and RNase H structural insights using selenium oligonucleotidesEvolution of a Transition State: Role of Lys100 in the Active Site of Isocitrate DehydrogenaseTransition state structure of arginine kinase: implications for catalysis of bimolecular reactionsCrystal structures of Flavobacterium glycosylasparaginase. An N-terminal nucleophile hydrolase activated by intramolecular proteolysisNew enzyme lineages by subdomain shufflingMillisecond Laue structures of an enzyme-product complex using photocaged substrate analogsStructures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activityKinetic Characterization of 100 Glycoside Hydrolase Mutants Enables the Discovery of Structural Features Correlated with Kinetic ConstantsEffects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reactionCombining structure and sequence information allows automated prediction of substrate specificities within enzyme familiesSingle-molecule force spectroscopy approach to enzyme catalysis.Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme.Theoretical insights in enzyme catalysis.Catalytic role of enzymes: short strong H-bond-induced partial proton shuttles and charge redistributions.Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes.Conformational diversity analysis reveals three functional mechanisms in proteins.In-Depth Dissection of the P133R Mutation in Steroid 5β-Reductase (AKR1D1): A Molecular Basis of Bile Acid DeficiencyViral destruction of cell surface receptors.X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus.Role of arginine 285 in the active site of Rhodotorula gracilis D-amino acid oxidase. A site-directed mutagenesis study.Protein dynamics and function from solution state NMR spectroscopy.The rate-determining steps of aldo-keto reductases (AKRs), a study on human steroid 5β-reductase (AKR1D1).
P2860
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P2860
Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Orbital steering in the cataly ...... h large catalytic consequences
@ast
Orbital steering in the cataly ...... h large catalytic consequences
@en
Orbital steering in the cataly ...... h large catalytic consequences
@nl
type
label
Orbital steering in the cataly ...... h large catalytic consequences
@ast
Orbital steering in the cataly ...... h large catalytic consequences
@en
Orbital steering in the cataly ...... h large catalytic consequences
@nl
prefLabel
Orbital steering in the cataly ...... h large catalytic consequences
@ast
Orbital steering in the cataly ...... h large catalytic consequences
@en
Orbital steering in the cataly ...... h large catalytic consequences
@nl
P3181
P1433
P1476
Orbital steering in the cataly ...... h large catalytic consequences
@en
P2093
B L Stoddard
D E Koshland
P304
P3181
P356
10.1126/SCIENCE.277.5323.202
P407
P577
1997-07-01T00:00:00Z