Structure of the proteasome activator REGalpha (PA28alpha)
about
Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core proteinMechanism of gate opening in the 20S proteasome by the proteasomal ATPasesStructural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101The structures of HsIU and the ATP-dependent protease HsIU-HsIVBlm10 protein promotes proteasomal substrate turnover by an active gating mechanismLysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta.Overview of protein structural and functional folds.The proteasome, a novel protease regulated by multiple mechanisms.The proteasome: a macromolecular assembly designed for controlled proteolysisThe proteasome activator 11 S REG (PA28) and class I antigen presentationPA28αβ: the enigmatic magic ring of the proteasome?Toward an atomic model of the 26S proteasome.Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes.Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes.Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies.Immunoproteasome subunit LMP2 expression is deregulated in Sjogren's syndrome but not in other autoimmune disorders.Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.Identification of an activation region in the proteasome activator REGalpha.Molecular machines for protein degradation.The pore of activated 20S proteasomes has an ordered 7-fold symmetric conformationThe ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death.Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.PA28γ is a novel corepressor of HTLV-1 replication and controls viral latency.High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications.Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis.Site-specific acetylation of the proteasome activator REGγ directs its heptameric structure and functions.Automated online sequential isotope labeling for protein quantitation applied to proteasome tissue-specific diversityExpanded polyglutamine-containing N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes.Structural insights into proteasome activation by the 19S regulatory particle.Proteasome activators.The role of the proteasome in the generation of MHC class I ligands and immune responses.Structural biology of the proteasome.Proteasome subtypes and regulators in the processing of antigenic peptides presented by class I molecules of the major histocompatibility complex.Proteasome activation by REG molecules lacking homolog-specific inserts.Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit.Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28.Potential allosteric modulators of the proteasome activity.Two-substrate association with the 20S proteasome at single-molecule level.Characterization of a REG/PA28 proteasome activator homolog in Dictyostelium discoideum indicates that the ubiquitin- and ATP-independent REGgamma proteasome is an ancient nuclear protease.
P2860
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P2860
Structure of the proteasome activator REGalpha (PA28alpha)
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Structure of the proteasome activator REGalpha (PA28alpha)
@ast
Structure of the proteasome activator REGalpha (PA28alpha)
@en
Structure of the proteasome activator REGalpha (PA28alpha)
@nl
type
label
Structure of the proteasome activator REGalpha (PA28alpha)
@ast
Structure of the proteasome activator REGalpha (PA28alpha)
@en
Structure of the proteasome activator REGalpha (PA28alpha)
@nl
prefLabel
Structure of the proteasome activator REGalpha (PA28alpha)
@ast
Structure of the proteasome activator REGalpha (PA28alpha)
@en
Structure of the proteasome activator REGalpha (PA28alpha)
@nl
P2093
P2860
P356
P1433
P1476
Structure of the proteasome activator REGalpha (PA28alpha)
@en
P2093
F G Whitby
J R Knowlton
M Rechsteiner
S C Johnston
P2860
P2888
P304
P356
10.1038/37670
P407
P577
1997-12-11T00:00:00Z
P6179
1041788186