Structural basis of inhibitor selectivity in MAP kinases - Wikidata - awgldk - TriplyDB

Structural basis of inhibitor selectivity in MAP kinases

Structural basis of inhibitor selectivity in MAP kinases

http://www.wikidata.org/entity/Q27765381

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Finding a better path to drug selectivity MKK3 was involved in larval settlement of the barnacle Amphibalanus amphitrite through activating the kinase activity of p38MAPK Crystal structure of aurora-2, an oncogenic serine/threonine kinase Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Å resolution Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design p38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational Analyses Structural Evaluation of Potent NKT Cell Agonists: Implications for Design of Novel Stimulatory Ligands Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual Screening In-plate protein crystallization, in situ ligand soaking and X-ray diffraction Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells Develop and test a solvent accessible surface area-based model in conformational entropy calculations A Src-like inactive conformation in the abl tyrosine kinase domain Identification of a Novel Inhibitory Allosteric Site in p38α Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.A role for p38 MAPK in the regulation of ciliary motion in a eukaryote.Efficient electrostatic solvation model for protein-fragment docking.Cross-interactions of two p38 mitogen-activated protein (MAP) kinase inhibitors and two cholecystokinin (CCK) receptor antagonists with the CCK1 receptor and p38 MAP kinase.How much NMR data is required to determine a protein-ligand complex structure?Prediction of specificity-determining residues for small-molecule kinase inhibitors.Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase.Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomics.Virtual target screening: validation using kinase inhibitors.The late-domain-containing protein p6 is the predominant phosphoprotein of human immunodeficiency virus type 1 particles.Perspective on the discovery and scientific impact of p38 MAP kinase.Development and strategies of VEGFR-2/KDR inhibitors.Polyphony: superposition independent methods for ensemble-based drug discovery.Azastilbenes: a cut-off to p38 MAPK inhibitors.Therapeutic modulation of inflammatory gene transcription by kinase inhibitors.Inclusion of multiple fragment types in the site identification by ligand competitive saturation (SILCS) approach CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK.The discovery of novel protein kinase inhibitors by using fragment-based high-throughput x-ray crystallography.SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice.

P2860

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P2860

Structural basis of inhibitor selectivity in MAP kinases

http://www.wikidata.org/entity/Q27765381

description

1998 nî lūn-bûn

@nan

1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

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1998年論文

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1998年論文

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1998年論文

@zh-hk

1998年論文

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1998年論文

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1998年论文

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name

Structural basis of inhibitor selectivity in MAP kinases

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Structural basis of inhibitor selectivity in MAP kinases

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Structural basis of inhibitor selectivity in MAP kinases

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type

label

Structural basis of inhibitor selectivity in MAP kinases

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Structural basis of inhibitor selectivity in MAP kinases

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Structural basis of inhibitor selectivity in MAP kinases

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prefLabel

Structural basis of inhibitor selectivity in MAP kinases

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Structural basis of inhibitor selectivity in MAP kinases

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Structural basis of inhibitor selectivity in MAP kinases

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Structural basis of inhibitor selectivity in MAP kinases

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B J Canagarajah

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E J Goldsmith

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J C Boehm

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J L Adams

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M H Cobb

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Z Wang

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1117-28

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scholarly article

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10.1016/S0969-2126(98)00113-0

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9

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