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The DNA Damage Response: Making It Safe to Play with Knives

The DNA Damage Response: Making It Safe to Play with Knives

http://www.wikidata.org/entity/Q27861055

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Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates A role for the malignant brain tumour (MBT) domain protein LIN-61 in DNA double-strand break repair by homologous recombination MicroRNAs in the DNA Damage/Repair Network and Cancer Epigenetic changes of DNA repair genes in cancer CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8 P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3 VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis The histone demethylase LSD1/KDM1A promotes the DNA damage response miRNA response to DNA damage Characterization of functional domains in human Claspin Shelterin complex and associated factors at human telomeres Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications AMP-activated protein kinase, stress responses and cardiovascular diseases Homologous recombination research is heating up and ready for therapy

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The DNA Damage Response: Making It Safe to Play with Knives

http://www.wikidata.org/entity/Q27861055

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

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2010年论文

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The DNA Damage Response: Making It Safe to Play with Knives

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The DNA Damage Response: Making It Safe to Play with Knives

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The DNA Damage Response: Making It Safe to Play with Knives

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The DNA Damage Response: Making It Safe to Play with Knives

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The DNA Damage Response: Making It Safe to Play with Knives

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The DNA Damage Response: Making It Safe to Play with Knives

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The DNA Damage Response: Making It Safe to Play with Knives

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The DNA Damage Response: Making It Safe to Play with Knives

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The DNA Damage Response: Making It Safe to Play with Knives

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J.MOLCEL.2010.09.019

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The DNA Damage Response: Making It Safe to Play with Knives

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Alberto Ciccia

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P2860

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

DNA Damage, Aging, and Cancer

Clarifying the mechanics of DNA strand exchange in meiotic recombination

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination

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179-204

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Stephen Elledge

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