The genetics of the p53 pathway, apoptosis and cancer therapy. - Wikidata - awgldk - TriplyDB

The genetics of the p53 pathway, apoptosis and cancer therapy.

The genetics of the p53 pathway, apoptosis and cancer therapy.

http://www.wikidata.org/entity/Q27863460

about

SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression Molecular origins of cancer: Molecular basis of colorectal cancer Anticancer effects of the nitric oxide-modified saquinavir derivative saquinavir-NO against multidrug-resistant cancer cells Molecular mechanisms that differentiate apoptosis from programmed necrosis Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients.Trial Watch: Proteasomal inhibitors for anticancer therapy Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1 Arsenic modulates posttranslational S-nitrosylation and translational proteome in keratinocytes Asbestos-induced lung diseases: an update ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth Simulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamics Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable.NVX-412, a new oncology drug candidate, induces S-phase arrest and DNA damage in cancer cells in a p53-independent manner Expression of TIP-1 confers radioresistance of malignant glioma cells On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53 A spiroligomer α-helix mimic that binds HDM2, penetrates human cells and stabilizes HDM2 in cell culture Antitumor activity of di-n-butyl-(2,6-difluorobenzohydroxamato)tin(IV) against human gastric carcinoma SGC-7901 cells via G2/M cell cycle arrest and cell apoptosis Myocardin is required for cardiomyocyte survival and maintenance of heart function Puma is required for p53-induced depletion of adult stem cells A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response SUMO-specific protease 2 in Mdm2-mediated regulation of p53 p53-independent roles of MDM2 in NF-κB signaling: implications for cancer therapy, wound healing, and autoimmune diseases A melanoma molecular disease model The emerging role of long non-coding RNAs in HIV infection.Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bδ gene.p53-mediated heterochromatin reorganization regulates its cell fate decisions.Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin.KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage.Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin.The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma.Targeting p53 for Novel Anticancer Therapy.Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB Apoptotic death of cancer stem cells for cancer therapy.Single-nucleotide polymorphisms in the p53 signaling pathway.Tumor suppressor RASSF1A promoter: p53 binding and methylation.MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner.

P2860

Q24298821-E9C75B30-C721-4000-929D-C328F043BFD0 Q24314416-16B735EA-1964-4A88-B2BD-F4E609B9477E Q24617331-AEE1A1A7-81EF-467C-B9AE-86213CDA01E5 Q24628715-6AB76935-78EE-4F29-AE2F-BC7C8E31D459 Q26829092-BAABB8DC-C61B-40B3-9D95-AD7206681292 Q27312673-7641C1B4-D715-406C-AEC1-87D060F10396 Q27853102-86FCD8A0-9D37-4758-BDD9-E20309F40E86 Q28082910-8B2D7D60-7BCB-4473-8812-3584B800B6D7 Q28115653-ACFB510B-3E72-4287-825A-5A76FADE6A6C Q28391587-2F52AE1B-5E05-4185-A103-8FDAB3357099 Q28393032-B20EC61D-CF82-4D1F-9E0A-D869BDDFE68B Q28477432-10D00DD3-CE72-4CB1-A989-BAF5704B8C8D Q28481334-3FA5562C-6F25-4775-8DF0-F74900BAD5F8 Q28482222-69F3F7EB-8799-4B9B-A3C2-18A1DE3E1E25 Q28482395-9AB8D4BB-BBDE-4560-AC48-C7A15DBDADCC Q28483767-DB70C110-AEF4-4CC1-B722-27B5E87EDE7E Q28483802-69CFD15A-D28A-4875-8BB7-C0C75E1929D0 Q28484086-A61565C8-B907-46E1-B46B-666486EAF38E Q28484490-322802C2-E5BC-4108-85DB-5E8EAEFD3BA4 Q28541026-E820DE09-0183-486A-90D1-23077207D055 Q28588163-FC434F92-205B-453B-BD00-A2EF11365523 Q28591824-B869FF27-C639-4535-81A5-DC8EA762E6C4 Q28592069-E6AB59E8-2F95-4E34-8555-DCCBA592221F Q28594151-B524DC3C-E41A-495B-BCCD-D2EC7B8F4C90 Q28611425-85BCFEE6-0FCE-4B28-911C-49AD5BD6E92E Q28741507-BA8CEF75-9F9A-4B95-AD8E-F6A2F74863EB Q30377278-AC13ACD8-010E-4602-BC59-8722212A65B7 Q31059965-B48A48B2-15D3-43F9-9AAE-670EF41D8CBD Q33565827-9DB5F437-1CF2-4040-8CF9-51715B19FD4F Q33578400-7B6888F2-1EB5-4208-9EB1-A40B626B73A2 Q33580494-033B9FB1-F864-4E69-B24C-6A50BC43CAEE Q33584237-A01FF05B-2BA4-4727-A592-6604C3C6CC1D Q33648709-0CE5A9D1-94B3-47E4-B803-259C523DA344 Q33655329-88485AD8-C28D-4184-A088-58EEB5C4DC02 Q33656653-B7D9B680-03A3-4DEE-B149-3AB5402C4BDD Q33755766-D6914089-602A-4336-9F2B-B994477C6749 Q33800384-0CFA8ED4-4009-49C0-80C4-CEA290FB726C Q33833892-4FB86ABA-E240-470E-A44E-3350AAC1BBD3 Q33869257-28091248-5194-428F-A63F-4BC2F7BC18B1 Q33930946-9983AECA-6916-4964-9815-71DCA1FE97B6

P2860

The genetics of the p53 pathway, apoptosis and cancer therapy.

http://www.wikidata.org/entity/Q27863460

description

2008 nî lūn-bûn

@nan

2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

The genetics of the p53 pathway, apoptosis and cancer therapy.

@ast

The genetics of the p53 pathway, apoptosis and cancer therapy.

@en

The genetics of the p53 pathway, apoptosis and cancer therapy.

@nl

type

label

The genetics of the p53 pathway, apoptosis and cancer therapy.

@ast

The genetics of the p53 pathway, apoptosis and cancer therapy.

@en

The genetics of the p53 pathway, apoptosis and cancer therapy.

@nl

altLabel

The genetics of the p53 pathway, apoptosis and cancer therapy

@en

prefLabel

The genetics of the p53 pathway, apoptosis and cancer therapy.

@ast

The genetics of the p53 pathway, apoptosis and cancer therapy.

@en

The genetics of the p53 pathway, apoptosis and cancer therapy.

@nl

P1433

Q27863460-B972C4AD-635D-4B47-AC8C-F5F7F5D7FEB7

P1476

Q27863460-045512E1-F134-4682-991E-23DBD9494FF3

P2093

Q27863460-0FA2A1F6-3AF4-4B9B-887D-03D862A289FC

Q27863460-2A9CC495-E48A-44E1-8BE6-37EC5FAF7D7E

Q27863460-97710375-964F-4B26-BD94-C5548B845DE8

P2860

Q27863460-0DE8E5B6-8E00-4E23-A7A8-7D9FF7DB25BA

Q27863460-111BFAB9-5D8B-4145-8D97-83006D976BFF

Q27863460-3D479A0D-DCBD-409A-9996-A4A24BD581DA

Q27863460-44EFDF24-EB04-4DD0-8603-CB15845C7031

Q27863460-59224AFD-8AE1-4608-883D-E578EC2906FB

Q27863460-67FFD8FA-2D34-48E9-9861-12942E52E114

Q27863460-6DFC479A-B780-4185-9AA9-E169365C8DD0

Q27863460-6ED8ECB0-2478-47DD-A111-F04D5AE09338

Q27863460-7E7E211C-1D80-4767-9927-7079F6107674

Q27863460-844453F3-D0A9-482B-8DA0-C984E25BEE14

P2888

Q27863460-87B96791-9556-442D-8EDB-48AE0956B029

P304

Q27863460-5F577A3C-11D4-44C4-9925-3B22BD9867CD

P31

Q27863460-95E1FBC0-94BB-4ED4-94E1-F2704580ECA7

P3181

Q27863460-5ED8D02F-61FE-498D-AA41-6165DC46F32D

P356

Q27863460-33CFA539-A01E-4D15-A1F1-23678F2953C8

P407

Q27863460-7ACC5315-F258-4A1E-97F9-C44E7E119373

P433

Q27863460-BCD96FC5-EEA2-4DFB-83DF-F3BEB99C232F

P478

Q27863460-DDDE878C-8F4A-4F81-9285-377D53BEF0E9

P50

Q27863460-E134708A-96B7-4759-92F3-565BBFA0BD74

P577

Q27863460-03EECE22-C395-48BC-9274-B87C825DC3D4

P5875

Q27863460-475B87D7-3342-4B4F-A662-836F642159E4

P6179

Q27863460-D4A58844-DFF8-464B-8292-9B2ADB693E4E

P698

Q27863460-599BAE63-D77A-4C11-8374-515203F921B1

P921

Q27863460-D3136F2B-E0F0-4343-87B8-74836EA78B8B

P3181

P356

P1433

Nature Reviews Drug Discovery

P1476

The genetics of the p53 pathway, apoptosis and cancer therapy.

@en

P2093

Arnold J Levine

http://www.w3.org/2001/XMLSchema#string

Elisabeth E Bond

http://www.w3.org/2001/XMLSchema#string

Gareth L Bond

http://www.w3.org/2001/XMLSchema#string

P2860

NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

p53, the cellular gatekeeper for growth and division

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

Functions of the MDM2 oncoprotein

P2888

P304

979-87

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2087749

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/NRD2656

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P50

P577

2008-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23556410

http://www.w3.org/2001/XMLSchema#string

P6179

1013821268

http://www.w3.org/2001/XMLSchema#string

P698

19043449

http://www.w3.org/2001/XMLSchema#string

P921

apoptotic process