Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains.
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Differential levels of p75NTR ectodomain in CSF and blood in patients with Alzheimer's disease: a novel diagnostic markerLoss of GABAergic cortical neurons underlies the neuropathology of Lafora diseaseThe in vivo brain interactome of the amyloid precursor proteinShedding of the p75NTR neurotrophin receptor is modulated by lipid raftsEndocytic down-regulation of ErbB2 is stimulated by cleavage of its C-terminus.Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds.Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptorNuclear localization of the p75 neurotrophin receptor intracellular domainA small region in the angiotensin-converting enzyme distal ectodomain is required for cleavage-secretion of the protein at the plasma membraneThe p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epitheliump75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17.TACE (ADAM17) inhibits Schwann cell myelination.Ectodomain shedding of interleukin-2 receptor beta and generation of an intracellular functional fragmentPro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis.Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation.p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's diseaseInduction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures.Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?Substrate specificity of gamma-secretase and other intramembrane proteases.Trafficking of receptor tyrosine kinases to the nucleusRole of tyrosine phosphorylation in the antioxidant effects of the p75 neurotrophin receptor.p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.Does the term 'trophic' actually mean anti-amyloidogenic? The case of NGF.Signals to promote myelin formation and repair.The many substrates of presenilin/γ-secretase.Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis.Nerve growth factor in diabetic retinopathy: beyond neurons.The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor.Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.Extracellular cleavage of the p75 neurotrophin receptor is implicated in its pro-survival effect in breast cancer cells.Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family membersSilencing p75(NTR) prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina.Imbalance of the Nerve Growth Factor and Its Precursor: Implication in Diabetic Retinopathy.Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons.Both positional and chemical variables control in vitro proteolytic cleavage of a presenilin ortholog.p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.Cleavage of p75 neurotrophin receptor is linked to Alzheimer's disease.Regulated intramembrane proteolysis: emergent role in cell signalling pathways.alpha-secretase cleaves the p75NTR extracellular domain
P2860
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P2860
Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains.
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Cleavage of p75 neurotrophin r ...... res specific receptor domains.
@ast
Cleavage of p75 neurotrophin r ...... res specific receptor domains.
@en
Cleavage of p75 neurotrophin r ...... res specific receptor domains.
@nl
type
label
Cleavage of p75 neurotrophin r ...... res specific receptor domains.
@ast
Cleavage of p75 neurotrophin r ...... res specific receptor domains.
@en
Cleavage of p75 neurotrophin r ...... res specific receptor domains.
@nl
altLabel
Cleavage of p75 neurotrophin r ...... ires specific receptor domains
@en
prefLabel
Cleavage of p75 neurotrophin r ...... res specific receptor domains.
@ast
Cleavage of p75 neurotrophin r ...... res specific receptor domains.
@en
Cleavage of p75 neurotrophin r ...... res specific receptor domains.
@nl
P356
P1476
Cleavage of p75 neurotrophin r ...... res specific receptor domains.
@en
P2093
Chong-Feng Xu
Thomas A Neubert
P304
P356
10.1074/JBC.M412957200
P407
P577
2005-04-15T00:00:00Z