Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
about
The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3LTri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicingTRAMP complex enhances RNA degradation by the nuclear exosome component Rrp6A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcriptsA unifying theory for general multigenic heterosis: energy efficiency, protein metabolism, and implications for molecular breedingSki2-like RNA helicase structures: common themes and complex assembliesMolecular Basis for Coordinating Transcription Termination with Noncoding RNA DegradationCo-transcriptional degradation by the 5'-3' exonuclease Rat1p mediates quality control of HXK1 mRNP biogenesis in S. cerevisiaeAn endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexesThe nuclear exosome is active and important during budding yeast meiosis.Altered RNA processing and export lead to retention of mRNAs near transcription sites and nuclear pore complexes or within the nucleolus.General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutantsR-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity.Nuclear mRNA quality control in yeast is mediated by Nrd1 co-transcriptional recruitment, as revealed by the targeting of Rho-induced aberrant transcripts.A BBP-Mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeast.The nuclear exosome and adenylation regulate posttranscriptional tethering of yeast GAL genes to the nuclear peripheryTrf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control.The DEAD-box RNA helicase Dbp2 connects RNA quality control with repression of aberrant transcription.Distinct roles of non-canonical poly(A) polymerases in RNA metabolism.An Rrp6-like protein positively regulates noncoding RNA levels and DNA methylation in Arabidopsis.Splice-site mutations cause Rrp6-mediated nuclear retention of the unspliced RNAs and transcriptional down-regulation of the splicing-defective genes.Comparative genomics of proteins involved in RNA nucleocytoplasmic export.Meiotic long non-coding meiRNA accumulates as a dot at its genetic locus facilitated by Mmi1 and plays as a decoy to lure Mmi1.RNA processing and exportThe human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decayAll things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay.Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiaeAir1 zinc knuckles 4 and 5 and a conserved IWRXY motif are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) RNA quality control complex.Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs.Oligoadenylation of 3' decay intermediates promotes cytoplasmic mRNA degradation in Drosophila cells.Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae.Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins.Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillanceNuclear RNA surveillance: role of TRAMP in controlling exosome specificity.Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutantsBimodal expression of PHO84 is modulated by early termination of antisense transcription.mRNA journey to the cytoplasm: attire required.The exosome associates cotranscriptionally with the nascent pre-mRNP through interactions with heterogeneous nuclear ribonucleoproteinsAssembly of an export-competent mRNP is needed for efficient release of the 3'-end processing complex after polyadenylationMutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability.
P2860
Q24317597-521BECF3-DAFA-49EA-B7D9-1BC29B7E9A5CQ24597002-182D48D2-2353-457C-A28F-A552C4B2F651Q24646718-C8204F70-BFF6-47C5-A745-088043780114Q24658122-EAC4C3E1-CA81-4EFA-B2A8-FF32896E35BBQ26809996-29EF5C9E-D8A5-468C-A5C1-397E9FFFD952Q26852748-5EE7AA0F-CAB0-4ADB-B94A-236A1253B61FQ27684832-227BB403-4DE6-4085-8020-13BCA2520053Q27929883-A41BA5C4-580C-4A82-83E2-66DCF5777D38Q27930062-DC7D40DC-9D0B-4C3C-A6C8-E7C9E2334F30Q27930582-6DC9E3FB-8811-4DB1-B5C7-796E0A39A557Q27930888-11D7F856-DF1B-48FA-8A5D-9EB9CDFD30D3Q27932821-31F142EF-5B3A-43D9-AA11-F43937109BCAQ27933182-32E0C4CD-F3B4-4ECB-B981-7850FA9B2457Q27936507-E6F967FD-B1EC-4BDE-9266-A0AE7900A492Q27937221-06BA8E1B-42FA-4F0A-B45B-B1A5E2EAE25DQ27937654-9A3BF3F7-10FB-4EF2-8C70-F295E4314AF4Q27937988-CCE2A1EE-A881-4778-B1EC-EA78B0FD230EQ27939370-C1E3570A-AAA1-41EA-9DF2-BAFD2EF6E290Q33480938-8C33995C-3A55-4B22-BF5F-EE176F148057Q33623094-C014D0CC-4839-4D24-BB46-5229C9BB4D92Q33633977-4914584B-F61E-4C57-9A0A-7266991A2844Q33790486-64530C67-4E29-436D-8DC2-66B53B056FDAQ33828505-7445577E-0E94-4C11-A663-8494E3DBE8CFQ34313748-5DEA9EF1-C2B0-449A-9552-64B25F722BB2Q35022339-6E3C7243-6981-4AAD-A5C7-5897E6544B9CQ35133366-CEEF3A4A-6E03-4F4A-84CB-46EEE5F7E985Q35262494-F52B944B-57B1-4621-82F9-585602EF95ECQ35423801-F3A1283C-A00F-4434-8A69-CA83274360FFQ35814334-231A32D5-A7D0-4B0B-B958-7138869C724BQ35898390-C9218878-DC3D-413A-9F6C-A067138B049CQ36114070-0A26BFF3-087A-4C78-A61A-ABF39853B5CAQ36129332-19F33173-D239-4258-8E83-3A00C40DBFD1Q36246643-C2834829-0BBD-42E8-9B20-4F78C5BAA139Q36626011-C8772DF8-81EA-41C2-821C-6F3CF83CB2A3Q36962852-CF01626E-2D92-41AD-887F-B19685332938Q37149974-DC340A16-86EF-4320-8D83-D121E05967CDQ37163404-8B67C3E0-ED36-4268-A3EF-E115364DD13DQ37285650-C6A89DBD-AA69-483E-8223-0A392549ACC0Q37355954-B2391C96-D277-4A56-8B25-CBF2D3088DC0Q37371769-8B02B5BF-73C8-4853-A38F-EDBF034F0468
P2860
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
@ast
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
@en
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
@nl
type
label
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
@ast
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
@en
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
@nl
prefLabel
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
@ast
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
@en
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
@nl
P2093
P2860
P3181
P356
P1433
P1476
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.
@en
P2093
Domenico Libri
Jens Raabjerg Olesen
Mathieu Rougemaille
Rajani Kanth Gudipati
Rune Thomsen
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601669
P407
P577
2007-05-02T00:00:00Z