Rap1 prevents telomere fusions by nonhomologous end joining.
about
Dubowitz syndrome is a complex comprised of multiple, genetically distinct and phenotypically overlapping disordersShelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeresCharacterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition siteStructural and Functional Studies of the Rap1 C-Terminus Reveal Novel Separation-of-Function MutantsThe orientation of the C-terminal domain of the Saccharomyces cerevisiae Rap1 protein is determined by its binding to DNAMating type influences chromosome loss and replicative senescence in telomerase-deficient budding yeast by Dnl4-dependent telomere fusion.Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex.End-joining inhibition at telomeres requires the translocase and polySUMO-dependent ubiquitin ligase Uls1.The transcriptional repressor activator protein Rap1p is a direct regulator of TATA-binding protein.Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signalMalaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIALocalization of telomeres and telomere-associated proteins in telomerase-negative Saccharomyces cerevisiaeHipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner.Dicentric breakage at telomere fusions.PRL-3 promotes telomere deprotection and chromosomal instability.To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity.Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance.Anticheckpoint pathways at telomeres in yeast.Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast.Telomerase is required to protect chromosomes with vertebrate-type T2AG3 3' ends in Saccharomyces cerevisiaeRad59-facilitated acquisition of Y' elements by short telomeres delays the onset of senescence.DNA breaks are masked by multiple Rap1 binding in yeast: implications for telomere capping and telomerase regulation.Minishelterins separate telomere length regulation and end protection in fission yeastAlternative arrangements of telomeric recognition sites regulate the binding mode of the DNA-binding domain of yeast Rap1.The role of nonhomologous end-joining components in telomere metabolism in Kluyveromyces lactisBinding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication.MRX-dependent DNA damage response to short telomeres.Mec1p associates with functionally compromised telomeresTelomeres: the beginnings and ends of eukaryotic chromosomes.Ontogeny of Unstable Chromosomes Generated by Telomere Error in Budding Yeast.Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome EndsRestricting the ligation step of non-homologous end-joining.Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeastYeast Est2p affects telomere length by influencing association of Rap1p with telomeric chromatin.Hypothesis: Paralog Formation from Progenitor Proteins and Paralog Mutagenesis Spur the Rapid Evolution of Telomere Binding Proteins.Multiple pathways inhibit NHEJ at telomeres.TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions.Nonrandom distribution of interhomolog recombination events induced by breakage of a dicentric chromosome in Saccharomyces cerevisiae.
P2860
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P2860
Rap1 prevents telomere fusions by nonhomologous end joining.
description
2005 nî lūn-bûn
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2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年學術文章
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name
Rap1 prevents telomere fusions by nonhomologous end joining.
@ast
Rap1 prevents telomere fusions by nonhomologous end joining.
@en
Rap1 prevents telomere fusions by nonhomologous end joining.
@nl
type
label
Rap1 prevents telomere fusions by nonhomologous end joining.
@ast
Rap1 prevents telomere fusions by nonhomologous end joining.
@en
Rap1 prevents telomere fusions by nonhomologous end joining.
@nl
prefLabel
Rap1 prevents telomere fusions by nonhomologous end joining.
@ast
Rap1 prevents telomere fusions by nonhomologous end joining.
@en
Rap1 prevents telomere fusions by nonhomologous end joining.
@nl
P2860
P3181
P356
P1433
P1476
Rap1 prevents telomere fusions by nonhomologous end joining.
@en
P2093
Benjamin Pardo
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7600778
P407
P577
2005-09-07T00:00:00Z