The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation
about
Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortionStructure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylationCEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the ciliumA direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylationOverexpression, purification, and functional analysis of recombinant human tubulin dimerThe chemical complexity of cellular microtubules: tubulin post-translational modification enzymes and their roles in tuning microtubule functionsThe Altered Hepatic Tubulin Code in Alcoholic Liver DiseaseManipulation of the host protein acetylation network by human immunodeficiency virus type 1Structure and mechanism of non-histone protein acetyltransferase enzymesExtracellular and Intracellular Signaling for Neuronal PolarityCell cycle progression by the repression of primary cilia formation in proliferating cellsScrutinizing ciliopathies by unraveling ciliary interaction networksThe role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologiesSperm Associated Antigen 6 (SPAG6) Regulates Fibroblast Cell Growth, Morphology, Migration and Ciliogenesis.Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasisMolecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase.Crystal structure of the intraflagellar transport complex 25/27Atomic resolution structure of human -tubulin acetyltransferase bound to acetyl-CoACrystal Structures of Tubulin Acetyltransferase Reveal a Conserved Catalytic Core and the Plasticity of the Essential N TerminusMolecular basis of the acetyltransferase activity of MEC-17 towards α-tubulinStructural and Functional Characterization of the α-Tubulin Acetyltransferase MEC-17Structural insights into HDAC6 tubulin deacetylation and its selective inhibitionαTAT1 catalyses microtubule acetylation at clathrin-coated pits.Type 3 adenylyl cyclase: a key enzyme mediating the cAMP signaling in neuronal ciliaDefining the orphan functions of lysine acetyltransferasesαTAT1 is the major α-tubulin acetyltransferase in miceRegulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulinAvrBsT acetylates Arabidopsis ACIP1, a protein that associates with microtubules and is required for immunityThe biological functions of Naa10 - From amino-terminal acetylation to human diseaseIndependent localization of plasma membrane and chloroplast components during eyespot assemblyGive chance a chanceAcetylated tubulin is essential for touch sensation in miceTgATAT-Mediated α-Tubulin Acetylation Is Required for Division of the Protozoan Parasite Toxoplasma gondiiRegulation of spindle integrity and mitotic fidelity by BCCIPMolecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1.Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesionTubulin acetyltransferase αTAT1 destabilizes microtubules independently of its acetylation activity.Loss of MEC-17 leads to microtubule instability and axonal degeneration.MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assemblyIncreasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.
P2860
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P2860
The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The major alpha-tubulin K40 ac ...... and efficient mechanosensation
@ast
The major alpha-tubulin K40 ac ...... and efficient mechanosensation
@en
The major alpha-tubulin K40 ac ...... nd efficient mechanosensation.
@nl
type
label
The major alpha-tubulin K40 ac ...... and efficient mechanosensation
@ast
The major alpha-tubulin K40 ac ...... and efficient mechanosensation
@en
The major alpha-tubulin K40 ac ...... nd efficient mechanosensation.
@nl
altLabel
The major alpha-tubulin K40 ac ...... and efficient mechanosensation
@en
prefLabel
The major alpha-tubulin K40 ac ...... and efficient mechanosensation
@ast
The major alpha-tubulin K40 ac ...... and efficient mechanosensation
@en
The major alpha-tubulin K40 ac ...... nd efficient mechanosensation.
@nl
P2093
P2860
P921
P3181
P356
P1476
The major alpha-tubulin K40 ac ...... and efficient mechanosensation
@en
P2093
Juan G Cueva
Miriam B Goodman
Toshinobu Shida
Zhenjie Xu
P2860
P304
21517-21522
P3181
P356
10.1073/PNAS.1013728107
P407
P577
2010-11-10T00:00:00Z