about
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase InhibitorsRegulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stressStructural basis for the regulated protease and chaperone function of DegPHtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cuesCrystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6Substrate-induced remodeling of the active site regulates human HTRA1 activityMolecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell EnvelopeStructural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin LigasesCrystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing MutationsStructure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing functionPlant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone DemethylasesRibosomal oxygenases are structurally conserved from prokaryotes to humansLysine methylation-dependent binding of 53BP1 to the pRb tumor suppressorHuman ISPD Is a Cytidyltransferase Required for Dystroglycan O-MannosylationMechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerizationStructural and mechanistic studies on γ-butyrobetaine hydroxylaseA multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron densityOutcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.Squeezing the most from every crystal: the fine details of data collection.Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii.Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitorStructure and inhibitor specificity of the PCTAIRE-family kinase CDK16.Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteinsStructure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.Proper modelling of ligand binding requires an ensemble of bound and unbound states.Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites.Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effectsSelectivity profiling of DegP substrates and inhibitors.Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control.Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligasesGentle, fast and effective crystal soaking by acoustic dispensingA Multi-Crystal Method for Extracting Obscured Signal from Crystallographic Electron DensityWhen protein crystal dehydration helpsCrystal structure of the protease domain of DegQ from Escherichia coliAspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Tobias Krojer
@ast
Tobias Krojer
@en
Tobias Krojer
@es
Tobias Krojer
@sl
type
label
Tobias Krojer
@ast
Tobias Krojer
@en
Tobias Krojer
@es
Tobias Krojer
@sl
prefLabel
Tobias Krojer
@ast
Tobias Krojer
@en
Tobias Krojer
@es
Tobias Krojer
@sl
P106
P21
P31
P496
0000-0003-0661-0814