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A century of cholesterol and coronaries: from plaques to genes to statins

A century of cholesterol and coronaries: from plaques to genes to statins

http://www.wikidata.org/entity/Q28080618

about

To Extinguish the Fire from Outside the Cell or to Shutdown the Gas Valve Inside? Novel Trends in Anti-Inflammatory Therapies PCSK9 inhibitors and cardiovascular disease: heralding a new therapeutic era Liver X receptors at the intersection of lipid metabolism and atherogenesis Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.Data gaps limit the translational potential of preclinical research.Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus.The elevation of plasma concentrations of apoB-48-containing lipoproteins in familial hypercholesterolemia is independent of PCSK9 levels.Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease.LDL-Cholesterol Increases the Transcytosis of Molecules through Endothelial Monolayers Cholesterol induces lipoprotein lipase expression in a tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease.Chronic administration of atorvastatin could partially ameliorate erectile function in streptozotocin-induced diabetic rats A Diet-Sensitive BAF60a-Mediated Pathway Links Hepatic Bile Acid Metabolism to Cholesterol Absorption and Atherosclerosis The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis.SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase.Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review.Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver Lovastatin exerts protective effects on endothelial cells via upregulation of PTK2B.Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis.Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization Microdomains, Inflammation, and Atherosclerosis.Angiogenesis in the atherosclerotic plaque.Half a Century Tales of Familial Hypercholesterolemia (FH) in Japan.Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease.Protective alleles and modifier variants in human health and disease.Semi-synthetic thymoquinone analogs: new prototypes as potential antihyperlipidemics in irradiated rats.Cholesterol metabolites and tumor microenvironment: the road towards clinical translation.Genetically engineered livestock for biomedical models.Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol.Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology.Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment.Targeting ApoC-III to Reduce Coronary Disease Risk.The early years of lipoprotein research: from discovery to clinical application.The interplay between cell signalling and the mevalonate pathway in cancer.ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.

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A century of cholesterol and coronaries: from plaques to genes to statins

http://www.wikidata.org/entity/Q28080618

description

2015 nî lūn-bûn

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2015 թուականի Մարտին հրատարակուած գիտական յօդուած

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2015 թվականի մարտին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

A century of cholesterol and coronaries: from plaques to genes to statins

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A century of cholesterol and coronaries: from plaques to genes to statins

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A century of cholesterol and coronaries: from plaques to genes to statins

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type

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A century of cholesterol and coronaries: from plaques to genes to statins

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A century of cholesterol and coronaries: from plaques to genes to statins

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A century of cholesterol and coronaries: from plaques to genes to statins

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prefLabel

A century of cholesterol and coronaries: from plaques to genes to statins

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A century of cholesterol and coronaries: from plaques to genes to statins

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A century of cholesterol and coronaries: from plaques to genes to statins

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Joseph L. Goldstein

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Michael S. Brown

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P2860

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity

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