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Novel Allosteric Modulators of G Protein-coupled Receptors

Novel Allosteric Modulators of G Protein-coupled Receptors

http://www.wikidata.org/entity/Q28081112

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Cannabinoid receptor type-1: breaking the dogmas Thematic Minireview Series: New Directions in G Protein-coupled Receptor Pharmacology Geomfinder: a multi-feature identifier of similar three-dimensional protein patterns: a ligand-independent approach Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands Emerging Computational Methods for the Rational Discovery of Allosteric Drugs.Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin.Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells.Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors.An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.What Do Structures Tell Us About Chemokine Receptor Function and Antagonism?Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions.Biased agonism and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus-induced gene 2.New winds in GPCR-based drug discovery.Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target.Organization and functions of mGlu and GABAB receptor complexes.Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities.Formyl Peptide Receptors in Mice and Men: Similarities and Differences in Recognition of Conventional Ligands and Modulating Lipopeptides.Allosteric Modulators of the CB1 Cannabinoid Receptor: A Structural Update Review.Dependence of prevalence of contiguous pathways in proteins on structural complexity.Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro.Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation.Biased signalling: from simple switches to allosteric microprocessors.Allosteric modulators of cannabinoid receptor 1: developing compounds for improved specificity.Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.A kinetic view of GPCR allostery and biased agonism.Activation processes in ligand-activated G protein-coupled receptors: A case study of the adenosine A2A receptor.Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.Prediction of consensus binding mode geometries for related chemical series of positive allosteric modulators of adenosine and muscarinic acetylcholine receptors.Allosteric modulation as a unifying mechanism for receptor function and regulation.Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations.Full rescue of an inactive olfactory receptor mutant by elimination of an allosteric ligand-gating site.Agonist-Biased Signaling via Matrix Metalloproteinase-9 Promotes Extracellular Matrix Remodeling Identification of Positive Allosteric Modulators of the D Dopamine Receptor That Act at Diverse Binding Sites

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Novel Allosteric Modulators of G Protein-coupled Receptors

http://www.wikidata.org/entity/Q28081112

description

2015 nî lūn-bûn

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2015 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի օգոստոսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Novel Allosteric Modulators of G Protein-coupled Receptors

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Novel Allosteric Modulators of G Protein-coupled Receptors

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Novel Allosteric Modulators of G Protein-coupled Receptors

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Novel Allosteric Modulators of G Protein-coupled Receptors

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Novel Allosteric Modulators of G Protein-coupled Receptors

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Novel Allosteric Modulators of G Protein-coupled Receptors

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Novel Allosteric Modulators of G Protein-coupled Receptors

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Novel Allosteric Modulators of G Protein-coupled Receptors

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Novel Allosteric Modulators of G Protein-coupled Receptors

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JBC.R115.662759

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Journal of Biological Chemistry

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Novel Allosteric Modulators of G Protein-coupled Receptors

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Arthur Christopoulos

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Patrick M. Sexton

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Patrick R. Gentry

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P2860

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Structure of class B GPCR corticotropin-releasing factor receptor 1

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.

The ensemble nature of allostery

Endogenous allosteric modulators of G protein-coupled receptors

Crystal structure of rhodopsin: A G protein-coupled receptor

Reversibly bound chloride in the atrial natriuretic peptide receptor hormone-binding domain: Possible allosteric regulation and a conserved structural motif for the chloride-binding site

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Patrick M. Sexton

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2015-06-22T00:00:00Z

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G protein-coupled receptor

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