The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
about
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's diseaseParkin mono-ubiquitinates Bcl-2 and regulates autophagySynaptic vesicle trafficking and Parkinson's diseaseAutoregulation of Parkin activity through its ubiquitin-like domainParkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell deathHow does parkin ligate ubiquitin to Parkinson's disease?Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studiesLinking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD)RBR E3 ubiquitin ligases: new structures, new insights, new questionsAtaxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse modelStructure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's diseaseSynaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic β-cellsSomatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channelsInjured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.Pruning and loss of excitatory synapses by the parkin ubiquitin ligaseSynaptotagmin-11 inhibits clathrin-mediated and bulk endocytosisLoss of locus coeruleus neurons and reduced startle in parkin null mice.Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.Parkin-mediated ubiquitination regulates phospholipase C-gamma1.Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene.Identification and characterization of a novel endogenous murine parkin mutation.Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease.Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.Upregulation of Parkin in endophilin mutant mice.Altered hippocampal synaptic physiology in aged parkin-deficient mice.Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells.Parkin mediates the degradation-independent ubiquitination of Hsp70Parkin and relatives: the RBR family of ubiquitin ligases.Aspects of innate immunity and Parkinson's disease.Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson diseaseManganese-induced toxicity in normal and human B lymphocyte cell lines containing a homozygous mutation in parkin.Recessive Parkinson's disease.Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2Parkinsonism genes: culprits and clues.The role of ubiquitin-protein ligases in neurodegenerative disease.Microtubule: a common target for parkin and Parkinson's disease toxins.The ring between ring fingers (RBR) protein familyThe Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates.Molecular pathways and genetic aspects of Parkinson's disease: from bench to bedside.Proteasome inhibition triggers activity-dependent increase in the size of the recycling vesicle pool in cultured hippocampal neurons.
P2860
1c8c23dc2b4dccc7f4f70d40eb046d403d77c930200f114e4e9d69fe8cd49bd19729545ff74120f32e6569c5c26bb70bddb61e404e01fa0c5c2b6a8c80e44ed5b07245b2b5f7dde90dd23e975f9ae46998772eb0257d96a6c74735ad3d2cbfa0cce29040c5046cd8704151e40476ba04c79bb6d7b6f9b9dccd75c731c9c9e589519d22facfe78c19504e0b97d609961426e1b09ccdb93990b5f62393aa3302c8
P248
Q21144949-6DA6DD4E-816D-43E8-88B7-22A87D9450B0Q24301563-B4A7DD62-4D23-4BBD-BC7A-F5091DED98BCQ24302024-01C1C911-DB27-4EE5-93A4-6E215074F86EQ24307382-B369B943-AC41-4F20-BED8-67FC0966BA84Q24313820-83F68206-C059-4C58-8F09-BD46BCFBE82BQ24537156-94BC38E6-DAD0-40B0-9155-B0CB11E5A355Q24606055-825AE164-517B-40B3-8DFB-2931CCE4D0CDQ26752685-66EC1D6D-C770-42F4-AFEA-255BC4AA6155Q26828565-CB1C4024-B378-4E33-B7E6-1EE7BE103342Q27311213-EC1863B1-C6DB-435C-BA6B-71AE89FF5072Q27644069-009D2433-2E1F-4E62-9D77-F6268AE0595FQ28118797-B0CB78BA-E3E1-48D9-8350-03EB509B1014Q28507955-37F5F11E-4F81-4BE4-8430-00470C7CD4EFQ28508854-FADEA89B-4AD6-428B-A202-BB54429D76F7Q28576054-982DAD16-1C6E-4472-A10E-22A0D09754ECQ28581207-7B3A54CD-80FA-4A19-BBB1-B9FCA18BB139Q28593443-097A7FDF-35A0-4B97-862C-DBA90DD9619EQ33577056-A0775FC9-6ED0-4EA8-B1B7-8BE03FF7205DQ33703497-20ACE2A7-F756-4050-B665-0D9C0F3668E9Q33782133-AF1A3AE7-E338-4870-BDCB-890F4165E474Q34012526-452EC974-6BE0-41D7-8060-1336FF6A5E11Q34372681-813F1506-4DF5-4663-BD4B-3923B8234679Q34528753-95D2D7BC-36D3-4A24-A4CA-2F6014C60088Q34614677-3E3C0252-253D-43F3-89EC-15075F054164Q35078309-321CA8A3-7C34-4001-A27F-F798ABB04FF1Q35208410-EE4716B8-5B63-4E11-B2BF-6C738245AF79Q35609973-8EDC7FEA-271D-42CE-84FC-74B6234A56D3Q35777606-D61E0F35-70F2-4B07-AA5C-384ADE6453ABQ35813131-C94890D9-8237-4A45-8FB2-76FD5FC52199Q35899904-F2A63CB1-AF08-4952-9AA2-42DC83F51DBCQ36223221-8F4E0E38-7885-49E4-A94B-6C0F658C4B68Q36449306-F61A792C-4CB5-4E07-8F26-2AC24174E0C2Q36477656-4F2F5FA3-67A0-4DEC-8C92-7D46E4AC65A8Q36534256-191AB994-260C-4096-8957-0CD1ECF56D55Q36565602-B37EE897-3EED-41FE-B3D3-1745FD52BB93Q36641831-60BB5E7E-8BAA-42C4-8C5A-DE6546A40A29Q36762636-42CF25F0-5A6D-4ACC-87B9-2851D625906CQ37003482-8840D7C7-99F3-4DFC-BD36-A48A5DE175E7Q37021321-A71CAC1F-408A-4458-8FBD-DAFC3E338B18Q37149682-0EAB61B3-8198-4C33-A06E-8B29406E2231
P2860
The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
description
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Oktober 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/10/15)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/10/15)
@nl
наукова стаття, опублікована в жовтні 2003
@uk
مقالة علمية (نشرت في 15-10-2003)
@ar
name
The autosomal recessive juveni ...... ubiquitinates synaptotagmin XI
@ast
The autosomal recessive juveni ...... ubiquitinates synaptotagmin XI
@en
The autosomal recessive juveni ...... ubiquitinates synaptotagmin XI
@nl
type
label
The autosomal recessive juveni ...... ubiquitinates synaptotagmin XI
@ast
The autosomal recessive juveni ...... ubiquitinates synaptotagmin XI
@en
The autosomal recessive juveni ...... ubiquitinates synaptotagmin XI
@nl
prefLabel
The autosomal recessive juveni ...... ubiquitinates synaptotagmin XI
@ast
The autosomal recessive juveni ...... ubiquitinates synaptotagmin XI
@en
The autosomal recessive juveni ...... ubiquitinates synaptotagmin XI
@nl
P2093
P3181
P356
P1476
The autosomal recessive juveni ...... ubiquitinates synaptotagmin XI
@en
P2093
Daniel R. Scoles
Dung Nguyen
Duong P. Huynh
Stefan M. Pulst
P304
P3181
P356
10.1093/HMG/DDG269
P577
2003-10-15T00:00:00Z