Hepatoprotective role of Sestrin2 against chronic ER stress
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose TissueJanus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domainsSestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signalingPhenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activitySesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation.Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.Upregulation of Sestrin2 expression protects against macrophage apoptosis induced by oxidized low-density lipoprotein.The potential of sestrins as therapeutic targets for diabetes.Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.Sestrin regulation of TORC1: Is Sestrin a leucine sensor?Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival.Biochemical Basis of Sestrin Physiological Activities.p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases.Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4.Statin and Bisphosphonate Induce Starvation in Fast-Growing Cancer Cell Lines.Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.Relative Alterations in Blood-Based Levels of Sestrin in Alzheimer's Disease and Mild Cognitive Impairment Patients.Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress.RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.Lipotoxicity induces hepatic protein inclusions through TBK1-mediated p62/SQSTM1 phosphorylation.Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum.Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.Autophagy Dysregulation and Obesity-Associated Pathologies.The Target of Rapamycin and Mechanisms of Cell Growth.
P2860
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P2860
Hepatoprotective role of Sestrin2 against chronic ER stress
description
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans Nature Communications
@fr
artículu científicu espublizáu en 2014
@ast
im Juni 2014 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2014/06/20)
@sk
vědecký článek publikovaný v roce 2014
@cs
wetenschappelijk artikel (gepubliceerd op 2014/06/20)
@nl
наукова стаття, опублікована в червні 2014
@uk
name
Hepatoprotective role of Sestrin2 against chronic ER stress
@ast
Hepatoprotective role of Sestrin2 against chronic ER stress
@en
Hepatoprotective role of Sestrin2 against chronic ER stress
@nl
type
label
Hepatoprotective role of Sestrin2 against chronic ER stress
@ast
Hepatoprotective role of Sestrin2 against chronic ER stress
@en
Hepatoprotective role of Sestrin2 against chronic ER stress
@nl
prefLabel
Hepatoprotective role of Sestrin2 against chronic ER stress
@ast
Hepatoprotective role of Sestrin2 against chronic ER stress
@en
Hepatoprotective role of Sestrin2 against chronic ER stress
@nl
P2093
P2860
P921
P356
P1476
Hepatoprotective role of Sestrin2 against chronic ER stress
@en
P2093
David N. Kim
Deqiang Zhang
Haeli Park
Hwan-Woo Park
Ian A. Semple
Insook Jang
Jun Hee Lee
Myeongjin Nam
Myungjin Kim
P2860
P2888
P356
10.1038/NCOMMS5233
P407
P577
2014-06-20T00:00:00Z
P5875
P6179
1032590349