Brk is coamplified with ErbB2 to promote proliferation in breast cancer
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In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissuesFrom single cells to tissues: interactions between the matrix and human breast cells in real timeProtein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrateProtein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factorPTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1SH2 Domains Recognize Contextual Peptide Sequence Information to Determine SelectivityCancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.Detection of Brk expression in non-small cell lung cancer: clinicopathological relevance.PTK6 regulates IGF-1-induced anchorage-independent survival.Brk/PTK6 signaling in normal and cancer cell models.Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRKEvolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapyMechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs.BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.Epithelial ovarian cancer stem-like cells expressing α-gal epitopes increase the immunogenicity of tumor associated antigensBrk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFRProtein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.Activated estrogen receptor-mitogen-activated protein kinases cross talk confer acquired resistance to lapatinib.Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.Expression of protein tyrosine kinase 6 (PTK6) in nonsmall cell lung cancer and their clinical and prognostic significance.Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast CancerHER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain.The expression and prognostic value of protein tyrosine kinase 6 in early-stage cervical squamous cell cancer.Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.DNA amplifications in breast cancer: genotypic-phenotypic correlations.Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology.Lapatinib resistance in HER2+ cancers: latest findings and new concepts on molecular mechanisms.Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo.PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms.
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P2860
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
description
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2008
@ast
im August 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/08/26)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/08/26)
@nl
наукова стаття, опублікована в серпні 2008
@uk
name
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
@ast
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
@en
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
@nl
type
label
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
@ast
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
@en
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
@nl
prefLabel
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
@ast
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
@en
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
@nl
P2093
P2860
P3181
P356
P1476
Brk is coamplified with ErbB2 to promote proliferation in breast cancer
@en
P2093
Alexander Krasnitz
Haoqun Qiu
Senthil K Muthuswamy
W Todd Miller
P2860
P304
12463-12468
P3181
P356
10.1073/PNAS.0805009105
P407
P577
2008-08-21T00:00:00Z