The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
about
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNAMutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinBDysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagensThe human RAD18 gene product interacts with HHR6A and HHR6BTwo novel human and mouse DNA polymerases of the polX familyCentrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repairInteractions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repairControlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitinDefining the function of xeroderma pigmentosum group F protein in psoralen interstrand cross-link-mediated DNA repair and mutagenesisInterferon regulatory factor 1 transactivates expression of human DNA polymerase η in response to carcinogen N-methyl-N'-nitro-N-nitrosoguanidinePrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replicationWerner syndrome protein interacts functionally with translesion DNA polymerasesRecognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forksHuman SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigenBreast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forksComplementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase etaDNA polymerase iota and related rad30-like enzymesMolecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patientsThe aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinomaUV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalizationHuman DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer terminiAltered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosinesMutations in human DNA polymerase eta motif II alter bypass of DNA lesionsStimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.Role of human DNA polymerase kappa as an extender in translesion synthesisRad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrestDNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2APhysical and functional interactions of human DNA polymerase eta with PCNANucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-linksRad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitinationEfficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappaXeroderma pigmentosumAll three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesisMisinsertion and bypass of thymine-thymine dimers by human DNA polymerase iotaError-prone bypass of certain DNA lesions by the human DNA polymerase kappapoliota, a remarkably error-prone human DNA polymeraseThe role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis
P2860
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P2860
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
description
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1999
@ast
scientific journal article
@en
vedecký článok (publikovaný 1999/06/17)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/06/17)
@nl
наукова стаття, опублікована в червні 1999
@uk
مقالة علمية (نشرت في 17-6-1999)
@ar
name
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
@ast
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
@en
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
@nl
type
label
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
@ast
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
@en
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
@nl
prefLabel
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
@ast
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
@en
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
@nl
P2093
P2860
P3181
P356
P1433
P1476
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
@en
P2093
Kusumoto R
Masutani C
P2860
P2888
P304
P3181
P356
10.1038/21447
P407
P50
P577
1999-06-01T00:00:00Z
P6179
1044849209