Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist
about
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonistThe chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalizationMolecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanismshCB2 ligand-interaction landscape: cysteine residues critical to biarylpyrazole antagonist binding motif and receptor modulation.An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis.The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signalingStructural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors-A Consequence of Evolutionary Pressure?Biased agonism and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus-induced gene 2.Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis.Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants.Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation.Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2.Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial.
P2860
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P2860
Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist
description
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Oktober 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/10/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/10/01)
@nl
наукова стаття, опублікована в жовтні 2008
@uk
مقالة علمية (نشرت في أكتوبر 2008)
@ar
name
Structural motifs of importanc ...... n in the absence of an agonist
@ast
Structural motifs of importanc ...... n in the absence of an agonist
@en
Structural motifs of importanc ...... n in the absence of an agonist
@nl
type
label
Structural motifs of importanc ...... n in the absence of an agonist
@ast
Structural motifs of importanc ...... n in the absence of an agonist
@en
Structural motifs of importanc ...... n in the absence of an agonist
@nl
prefLabel
Structural motifs of importanc ...... n in the absence of an agonist
@ast
Structural motifs of importanc ...... n in the absence of an agonist
@en
Structural motifs of importanc ...... n in the absence of an agonist
@nl
P356
P1476
Structural motifs of importanc ...... n in the absence of an agonist
@en
P2093
Tau Benned-Jensen
P304
P356
10.1124/MOL.108.049676
P577
2008-10-01T00:00:00Z