The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
about
Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alphaRegional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CARCross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factorsDec1 and Dec2 are regulators of the mammalian molecular clockDEC1 modulates the circadian phase of clock gene expressionThe xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CARPhenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B genePossible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalaciaReduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alphaAlternatively spliced isoforms of the human constitutive androstane receptorDiurnal difference in CAR mRNA expressionComplex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CARUnderstanding the human health effects of chemical mixtures.Regulation of the cytosolic sulfotransferases by nuclear receptorsModulation of xenobiotic receptors by steroidsInsights into CYP2B6-mediated drug-drug interactionsIdentification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbitalIdentification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesPhenobarbital confers its diverse effects by activating the orphan nuclear receptor carPhenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signalingAMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell lineXenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligandsShort-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans ratsCREBH determines the severity of sulpyrine-induced fatal shockThe roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse liversTransactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) ActivationOverexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liverPredictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals.Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45BSexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Phenobarbital Meets Phosphorylation of Nuclear ReceptorsProteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.Tissue-specific chromatin structure of the phenobarbital-responsive unit and proximal promoter of CYP2B1/2 and modulation by phenobarbital.Dietary flavonoids activate the constitutive androstane receptor (CAR).Clinical application of transcriptional activators of bile salt transporters.Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.
P2860
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P2860
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The repressed nuclear receptor ...... tivating the human CYP2B6 gene
@ast
The repressed nuclear receptor ...... tivating the human CYP2B6 gene
@en
The repressed nuclear receptor ...... tivating the human CYP2B6 gene
@nl
type
label
The repressed nuclear receptor ...... tivating the human CYP2B6 gene
@ast
The repressed nuclear receptor ...... tivating the human CYP2B6 gene
@en
The repressed nuclear receptor ...... tivating the human CYP2B6 gene
@nl
prefLabel
The repressed nuclear receptor ...... tivating the human CYP2B6 gene
@ast
The repressed nuclear receptor ...... tivating the human CYP2B6 gene
@en
The repressed nuclear receptor ...... tivating the human CYP2B6 gene
@nl
P2093
P2860
P3181
P356
P1476
The repressed nuclear receptor ...... tivating the human CYP2B6 gene
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.274.10.6043
P407
P577
1999-03-05T00:00:00Z