Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification
about
An enlarged parietal foramen in the late archaic Xujiayao 11 neurocranium from Northern China, and rare anomalies among Pleistocene HomoMedical sequencing of candidate genes for nonsyndromic cleft lip and palateThe ALX4 homeobox gene is mutated in patients with ossification defects of the skull (foramina parietalia permagna, OMIM 168500)Haploinsufficiency of ALX4 as a potential cause of parietal foramina in the 11p11.2 contiguous gene-deletion syndromeLoss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determinationEnlarged parietal foramina caused by mutations in the homeobox genes ALX4 and MSX2: from genotype to phenotypeMechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4Transcriptional regulatory cascades in Runx2-dependent bone developmentRegulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distributionClinical and molecular analysis of nine families with Adams-Oliver syndromeEssential role for NFI-C/CTF transcription-replication factor in tooth root developmentReciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiationYY1 activates Msx2 gene independent of bone morphogenetic protein signaling.Msx1 disruption leads to diencephalon defects and hydrocephalusDistinct global shifts in genomic binding profiles of limb malformation-associated HOXD13 mutationsMsx2 is a repressor of chondrogenic differentiation in migratory cranial neural crest cellsSkeletal gene expression in the temporal region of the reptilian embryos: implications for the evolution of reptilian skull morphologySignals and switches in Mammalian neural crest cell differentiationDerivation of the mammalian skull vaultA genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9Avian facial morphogenesis is regulated by c-Jun N-terminal kinase/planar cell polarity (JNK/PCP) wingless-related (WNT) signaling.Domain duplication, divergence, and loss events in vertebrate Msx paralogs reveal phylogenomically informed disease markers.Phenotypic analysis of Dlx5 overexpression in post-natal bone.Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures.Molecular evolution of the homeodomain family of transcription factorsMsx2 mediates the inhibitory action of TNF-alpha on osteoblast differentiation.Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.Characterization of a new syndrome that associates craniosynostosis, delayed fontanel closure, parietal foramina, imperforate anus, and skin eruption: CDAGS.Ectodermal dysplasias: not only 'skin' deep.Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro.Missense mutations of human homeoboxes: A review.Initiation of early osteoblast differentiation events through the direct transcriptional regulation of Msx2 by FOXC1Bilateral radial agenesis with absent thumbs, complex heart defect, short stature, and facial dysmorphism in a patient with pure distal microduplication of 5q35.2-5q35.3.Molecular-pathogenetic classification of genetic disorders of the skeleton.PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.Ameloblastin inhibits cranial suture closure by modulating MSX2 expression and proliferationMsx1 mutations: how do they cause tooth agenesis?Genetically altered mouse models: the good, the bad, and the ugly.Actual concepts in scaphocephaly : (an experience of 98 cases).
P2860
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P2860
Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification
description
2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
@wuu
name
Functional haploinsufficiency ...... defects in skull ossification
@ast
Functional haploinsufficiency ...... defects in skull ossification
@en
Functional haploinsufficiency ...... defects in skull ossification
@nl
type
label
Functional haploinsufficiency ...... defects in skull ossification
@ast
Functional haploinsufficiency ...... defects in skull ossification
@en
Functional haploinsufficiency ...... defects in skull ossification
@nl
prefLabel
Functional haploinsufficiency ...... defects in skull ossification
@ast
Functional haploinsufficiency ...... defects in skull ossification
@en
Functional haploinsufficiency ...... defects in skull ossification
@nl
P2093
P356
P1433
P1476
Functional haploinsufficiency ...... defects in skull ossification
@en
P2093
A O Wilkie
K H Chrzanowska
R E Maxson
P2888
P304
P356
10.1038/74224
P407
P577
2000-04-01T00:00:00Z
P5875
P6179
1039286918