The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes
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ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome.Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding.Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDMRole of ZAC1 in transient neonatal diabetes mellitus and glucose metabolismPathogenesis of the metabolic syndrome: insights from monogenic disordersGenetics and pathophysiology of neonatal diabetes mellitus.Regulatory links between imprinted genes: evolutionary predictions and consequencesAlternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activitiesLOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancerCharacterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatinDifferential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression.Patterns of hybrid loss of imprinting reveal tissue- and cluster-specific regulationMecp2-null mice provide new neuronal targets for Rett syndrome.Discovery of imprinted transcripts in the mouse transcriptome using large-scale expression profilingThe Missing lnc(RNA) between the pancreatic β-cell and diabetesPartial paternal uniparental disomy of chromosome 6 in an infant with neonatal diabetes, macroglossia, and craniofacial abnormalities.Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes.Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure.Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse (Mus musculus).Medical care from childhood to adulthood in type 1 and type 2 diabetes.Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic β cell line MIN6.Identification of novel imprinted genes in a genome-wide screen for maternal methylation.Transient neonatal diabetes, a disorder of imprinting.American College of Medical Genetics statement of diagnostic testing for uniparental disomyCell-type and transcription factor specific enrichment of transcriptional cofactor motifs in ENCODE ChIP-seq dataDiabetes in the young: a paediatric and epidemiological perspective.Germline and somatic imprinting in the nonhuman primate highlights species differences in oocyte methylation.High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes.Putative tumor suppressor loci at 6q22 and 6q23-q24 are involved in the malignant progression of sporadic endocrine pancreatic tumors.Unlocking the secrets of the pancreatic beta cell: man and mouse provide the key.A novel variation of PLAGL1 in Chinese patients with isolated ventricular septal defectQ-RRBS: a quantitative reduced representation bisulfite sequencing method for single-cell methylome analyses.Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop.Growth regulation, imprinted genes, and chromosome 11p15.5.The role of epigenetics in idiopathic male infertility.Effects of in vitro maturation on gene expression in rhesus monkey oocytesAssociations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspringGenetic and epigenetic defects at the 6q24 imprinted locus in a cohort of 13 patients with transient neonatal diabetes: new hypothesis raised by the finding of a unique case with hemizygotic deletion in the critical region.Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt
P2860
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P2860
The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes
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2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
@wuu
name
The cell cycle control gene ZA ...... or transient neonatal diabetes
@ast
The cell cycle control gene ZA ...... or transient neonatal diabetes
@en
The cell cycle control gene ZA ...... or transient neonatal diabetes
@nl
type
label
The cell cycle control gene ZA ...... or transient neonatal diabetes
@ast
The cell cycle control gene ZA ...... or transient neonatal diabetes
@en
The cell cycle control gene ZA ...... or transient neonatal diabetes
@nl
prefLabel
The cell cycle control gene ZA ...... or transient neonatal diabetes
@ast
The cell cycle control gene ZA ...... or transient neonatal diabetes
@en
The cell cycle control gene ZA ...... or transient neonatal diabetes
@nl
P2093
P356
P1476
The cell cycle control gene ZA ...... or transient neonatal diabetes
@en
P2093
K Kamimura
K Satomura
M Kusakabe
M Muramatsu
P304
P356
10.1093/HMG/9.3.453
P407
P577
2000-02-01T00:00:00Z