Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains
about
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathwayThe DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressorp53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loopMCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-MThe C terminus of p53 family proteins is a cell fate determinantMapping the interactions of the p53 transactivation domain with the KIX domain of CBPMultivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damageFour domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesDefinition of the p53 functional domains necessary for inducing apoptosis.Strategies for manipulating the p53 pathway in the treatment of human cancer.Shared structural features of the 9aaTAD family in complex with CBP.Molecular basis for modulation of the p53 target selectivity by KLF4.Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.Mutant p53: one name, many proteins.Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53.Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence.Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype.Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways.The tumor suppressor p53: from structures to drug discovery.p53: the attractive tumor suppressor in the cancer research field.Deconstructing p53 transcriptional networks in tumor suppression.Role of p53 in Cell Death and Human Cancers.Illuminating p53 function in cancer with genetically engineered mouse models.Dissecting functional roles of p53 N-terminal transactivation domains by microarray expression analysis.Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.The Transactivation Domains of the p53 Protein.Effects of stability on the biological function of p53.Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.Changes in p53 expression in mouse fibroblasts can modify motility and extracellular matrix organization.HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration.Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics.Genome-wide analysis of p53 under hypoxic conditions.Guilty as CHARGED: p53's expanding role in disease.Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein.The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality.Cytokinin Response Factor 5 has transcriptional activity governed by its C-terminal domain.Mechanisms of transcriptional regulation by p53.Deconstructing networks of p53-mediated tumor suppression in vivo.
P2860
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P2860
Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Definition of a p53 transactiv ...... p53 transactivation subdomains
@ast
Definition of a p53 transactiv ...... p53 transactivation subdomains
@en
Definition of a p53 transactiv ...... p53 transactivation subdomains
@nl
type
label
Definition of a p53 transactiv ...... p53 transactivation subdomains
@ast
Definition of a p53 transactiv ...... p53 transactivation subdomains
@en
Definition of a p53 transactiv ...... p53 transactivation subdomains
@nl
prefLabel
Definition of a p53 transactiv ...... p53 transactivation subdomains
@ast
Definition of a p53 transactiv ...... p53 transactivation subdomains
@en
Definition of a p53 transactiv ...... p53 transactivation subdomains
@nl
P2093
P356
P1433
P1476
Definition of a p53 transactiv ...... p53 transactivation subdomains
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1202539
P407
P577
1999-04-08T00:00:00Z
P5875
P6179
1052464397